PDF(Pubmed)
Abstract：
This meta-analysis aimed to summarise clinical evidence regarding the effect of supplementation with cornelian cherry (Cornus mas L.) on different cardiometabolic outcomes. An extensive literature survey was carried out until 10 April 2024. A total of 415 participants from six eligible studies were included. The overall results from the random-effects model indicated that cornelian cherry supplementation significantly reduced body weight (standardised mean difference [SMD] = -0.27, confidence interval [CI]: -0.52, -0.02, p = 0.03), body mass index (SMD = -0.42, CI: -0.73, -0.12, p = 0.007), fasting blood glucose (SMD = -0.46, CI: -0.74, -0.18, p = 0.001), glycated haemoglobin (SMD = -0.70, CI: -1.19, -0.22, p = 0.005), and HOMA-IR (SMD = -0.89, CI: -1.62, -0.16, p = 0.02), while high-density lipoprotein cholesterol significantly increased (SMD = 0.38, CI: 0.10, 0.65, p = 0.007). A sensitivity analysis showed that cornelian cherry supplementation significantly reduced total plasma triglycerides, total cholesterol, low-density lipoprotein cholesterol, and insulin levels. Cornelian cherry supplementation did not significantly affect waist circumference and liver parameters among the participants. Considering these findings, this meta-analysis indicates that supplementation with cornelian cherry may impact diverse cardiometabolic risk factors among individuals considered to be at a high risk.
摘要：
这项荟萃分析旨在总结有关补充山茱萸樱桃（CornusmasL.）对不同心脏代谢结果的影响的临床证据。进行了广泛的文献调查，直到2024年4月10日。共纳入来自6项符合条件的研究的415名参与者。随机效应模型的总体结果表明，补充山茱萸樱桃可显着降低体重（标准化平均差[SMD]=-0.27，置信区间[CI]：-0.52，-0.02，p=0.03），体重指数（SMD=-0.42，CI：-0.73，-0.12，p=0.007），空腹血糖（SMD=-0.46，CI：-0.74，-0.18，p=0.001），糖化血红蛋白（SMD=-0.70，CI：-1.19，-0.22，p=0.005），和HOMA-IR(SMD=-0.89，CI：-1.62，-0.16，p=0.02)，而高密度脂蛋白胆固醇显著升高(SMD=0.38,CI:0.10,0.65,p=0.007)。敏感性分析表明，补充山茱萸樱桃可显着降低血浆总甘油三酯，总胆固醇,低密度脂蛋白胆固醇，和胰岛素水平。补充Cornelian樱桃对参与者的腰围和肝脏参数没有显着影响。考虑到这些发现,这项荟萃分析显示,在被认为高危人群中,补充山茱萸樱桃可能会影响不同的心脏代谢危险因素.
