PDF(Pubmed)
Abstract：
Lifestyle factors, such as diet and sleep quality, are receiving increasing interest as accessible therapeutic approaches to migraine. The Mediterranean diet (MD) has shown clear benefits in cardiovascular and metabolic diseases, as well as in sleep patterns. Here, our objective was to identify the impact of adherence to the MD and other lifestyle factors on the clinical burden of migraine. For this purpose, we enrolled 170 migraine patients and 100 controls, assessing the clinical disability of headache using standardized clinical scales (HIT-6 and MIDAS) in the migraineur cohort and lifestyle patterns in both groups through the PREDIMED score for MD adherence, the IPAQ scale for physical activity, and BMI. Subjects were also screened for sleep-wake disturbances based on the Pittsburgh Sleep Quality Index (PSQI). We found that migraine patients had lower adherence to the MD compared to the controls and that the HIT-6 scale had a significant negative relationship with MD adherence in patients with high-frequency episodic and chronic migraine. Additionally, in the same migraine patients, the presence of sleep-wake disturbances was correlated with greater migraine disability as assessed by the MIDAS score. In conclusion, this study found that among different lifestyle factors, poor adherence to the MD and the presence of sleep-wake disturbances were closely associated with migraine disability and chronification.
摘要：
生活方式因素,比如饮食和睡眠质量，作为偏头痛的可获得治疗方法，人们越来越感兴趣。地中海饮食（MD）在心血管和代谢疾病中显示出明显的益处，以及睡眠模式。这里,我们的目的是确定坚持MD和其他生活方式因素对偏头痛临床负担的影响.为此,我们招募了170名偏头痛患者和100名对照，在偏头痛队列中使用标准化临床量表（HIT-6和MIDAS）评估头痛的临床残疾，并通过MD依从性的PREDIMED评分评估两组的生活方式，体育活动的IPAQ量表，BMI。还基于匹兹堡睡眠质量指数(PSQI)筛选受试者的睡眠-觉醒障碍。我们发现，与对照组相比，偏头痛患者对MD的依从性较低，并且HIT-6量表与高频发作性和慢性偏头痛患者的MD依从性呈显着负相关。此外,在同样的偏头痛患者中，根据MIDAS评分评估,睡眠-觉醒障碍的存在与更大的偏头痛残疾相关.总之,这项研究发现，在不同的生活方式因素中，对MD的依从性差和睡眠-觉醒障碍的存在与偏头痛残疾和慢性化密切相关.
