PDF(Pubmed)
Abstract：
Pre-pregnancy body mass index (pBMI) is a predictor of gestational weight gain (GWG). However, other factors, such as adipokines and inflammation markers, may also be associated with GWG. The aim of the study was to determine the association of leptin, adiponectin, irisin, and C-reactive protein, with GWG in adolescents. A longitudinal study was conducted from 2018 to 2023 in adolescents with a clinically healthy pregnancy. The assessments included sociodemographic and clinical data, pBMI, percent of body fat, serum concentrations of leptin, adiponectin, irisin, and high-sensitivity C-reactive protein (hsCRP), and total GWG adequacy. Cox regression models were performed, the outcome variables were inadequate and excessive GWG. In 198 participants, being overweight/obesity was marginally associated with a protective effect against inadequate GWG (HR = 0.44, 95%CI = 0.18-1.06), regardless of maternal characteristics and adipokines. Leptin (HR = 1.014, 95%CI = 1.008-1.021), and body fat percent (HR = 1.11, 95%CI = 1.05-1.17) were associated with a higher risk of excessive GWG, independent of other maternal variables such as pBMI, while adiponectin was associated with a lower risk. These findings suggest that, in Mexican adolescents, adipose tissue and its adipokines during pregnancy may play a more significant role in the final GWG than body weight.
摘要：
孕前体重指数（pBMI）是妊娠期体重增加（GWG）的预测指标。然而,其他因素,如脂肪因子和炎症标志物，也可以与GWG相关联。这项研究的目的是确定瘦素的相关性，脂联素,irisin,和C反应蛋白,在青少年中使用GWG。从2018年到2023年，在临床健康怀孕的青少年中进行了一项纵向研究。评估包括社会人口统计学和临床数据，pBMI,身体脂肪的百分比，血清瘦素浓度，脂联素,irisin,高敏C反应蛋白（hsCRP），和总GWG充足性。进行了Cox回归模型，结果变量不足和过高的GWG。在198名参与者中，超重/肥胖与对不足GWG的保护作用轻微相关（HR=0.44，95CI=0.18-1.06），不管母亲的特征和脂肪因子。瘦素（HR=1.014，95CI=1.008-1.021），和体脂百分比（HR=1.11，95CI=1.05-1.17）与更高的GWG过度风险相关，独立于其他母亲变量，如pBMI，而脂联素与较低的风险相关。这些发现表明,在墨西哥青少年中，妊娠期间的脂肪组织及其脂肪因子在最终GWG中的作用可能比体重更重要。
