PDF(Pubmed)
Abstract：
Hypertension remains a major global public health crisis due to various contributing factors, such as age and environmental exposures. This study delves into exploring the intricate association between biological aging, blood lead levels, and hypertension, along with examining the mediating role of blood lead levels in the relationship between biological aging and hypertension. We analyzed data from two cycles of the NHANES, encompassing 4473 individuals aged 18 years and older. Our findings indicate that biological aging potentially escalates the risk of hypertension and the incidences of systolic blood pressure (SBP) and diastolic blood pressure (DBP) abnormalities. Utilizing weighted quantile sum (WQS) and quantile g-computation (QGC) model analyses, we observed that exposure to heavy metal mixtures, particularly lead, may elevate the likelihood of hypertension, SBP, and DBP abnormalities. Further mediation analysis revealed that lead significantly mediated the relationship between biological aging and hypertension and between biological aging and SBP abnormalities, accounting for 64% (95% CI, 49% to 89%) and 64% (95% CI, 44% to 88%) of the effects, respectively. These outcomes emphasize the criticality of implementing environmental health measures.
摘要：
由于各种促成因素，高血压仍然是全球主要的公共卫生危机，例如年龄和环境暴露。这项研究探讨了生物衰老之间的复杂关联，血铅水平,和高血压，同时研究血铅水平在生物衰老与高血压关系中的中介作用。我们分析了NHANES的两个周期的数据，包括4473名18岁及以上的人。我们的发现表明，生物衰老可能会增加高血压的风险以及收缩压（SBP）和舒张压（DBP）异常的发生率。利用加权分位数和(WQS)和分位数g计算(QGC)模型分析，我们观察到接触重金属混合物，尤其是铅,可能会增加高血压的可能性，SBP,和DBP异常。进一步的中介分析显示，铅显著介导了生物衰老与高血压之间的关系以及生物衰老与SBP异常之间的关系，占效应的64%(95%CI，49%至89%)和64%(95%CI，44%至88%)，分别。这些结果强调了实施环境卫生措施的重要性。
