PDF(Pubmed)
Abstract：
Obesity and overweight pose significant risks to health, contributing to the prevalence of chronic conditions like type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). The current study aimed to assess the impact of a 6-year nutritional and lifestyle intervention on oxidative and inflammatory markers in individuals aged 55 to 75, specifically those at high risk of CVD. A study was carried out in a group of 80 participants with metabolic syndrome (MetS) residing in Mallorca, Spain, who underwent nutritional intervention based on a low-calorie Mediterranean diet (MedDiet) and promotion of physical activity. Before and after the intervention, several parameters including anthropometric data, haematological factors, blood pressure, and physical activity level were measured. Oxidative and inflammatory biomarkers in plasma were analysed. After the 6-year intervention, participants who managed to reduce their body mass index (BMI) had greater reductions in abdominal obesity, waist to heigh ratio (WHtR), diastolic blood pressure, and glucose levels, and increased high density protein cholesterol (HDL-c) compared to those who did not reduce BMI. This higher reduction in BMI was related to reduced energy intake and increased adherence to MedDiet, with greater polyphenol intake, and total physical activity (PA). Furthermore, improvements in oxidative stress and proinflammatory status were observed in participants who reduced their BMI. Significant reductions in the activity of the prooxidant enzyme, myeloperoxidase (MPO), levels of the lipid oxidation marker, malondialdehyde (MDA), and the proinflammatory chemokine, monocyte chemoattractant protein-1 (MCP-1,) were found in those who reduced their BMI. In contrast, participants who did not improve their BMI exhibited higher levels of proinflammatory markers such as MCP-1 and tumour necrosis factor α (TNFα), as well as increased activity of the antioxidant enzyme catalase (CAT). Current findings suggest that an effective way to reduce BMI is a hypocaloric MedDiet combined with tailored physical activity to improve oxidative stress and proinflammatory status, and potentially reducing the risk of CVD.
摘要：
肥胖和超重对健康构成重大风险，导致2型糖尿病（T2DM）和心血管疾病（CVD）等慢性疾病的患病率。本研究旨在评估6年营养和生活方式干预对55至75岁人群，特别是心血管疾病高危人群的氧化和炎症标志物的影响。对居住在马洛卡的80名代谢综合征（MetS）参与者进行了一项研究，西班牙,他们接受了基于低热量地中海饮食（MedDiet）和促进体育锻炼的营养干预。干预前后,几个参数，包括人体测量数据，血液学因素，血压,和身体活动水平进行了测量。分析血浆中的氧化和炎性生物标志物。经过6年的干预，设法降低体重指数（BMI）的参与者腹部肥胖的减少幅度更大，腰围高度比（WHtR），舒张压,和葡萄糖水平，与未降低BMI的人相比，高密度蛋白胆固醇（HDL-c）增加。BMI较高的降低与能量摄入减少和对MedDiet的依从性增加有关，随着多酚的摄入量增加，和总体力活动（PA）。此外，在BMI降低的参与者中观察到氧化应激和促炎状态的改善.促氧化酶的活性显著降低，髓过氧化物酶(MPO),脂质氧化标记物的水平，丙二醛（MDA），和促炎趋化因子，单核细胞趋化蛋白-1(MCP-1)在降低BMI的人群中被发现。相比之下,未改善BMI的参与者表现出更高水平的促炎标志物，如MCP-1和肿瘤坏死因子α（TNFα），以及抗氧化酶过氧化氢酶（CAT）的活性增加。目前的研究结果表明，降低BMI的有效方法是低热量的MedDiet与量身定制的体育锻炼相结合，以改善氧化应激和促炎状态。并可能降低CVD的风险。
