PDF(Pubmed)
Abstract：
Current evidence suggests a beneficial role of herbal products in free radical-induced diseases. Panax notoginseng (Burk.) F. H. Chen has long occupied a leading position in traditional Chinese medicine because of the ergogenic, nootropic, and antistress activities, although these properties are also acknowledged in the Western world. The goal of this paper is to review the pharmacological and toxicological properties of P. notoginseng and discuss its potential therapeutic effect. A literature search was carried out on Pubmed, Scopus, and the Cochrane Central Register of Controlled Trials databases. The following search terms were used: \"notoginseng\", \"gut microbiota\", \"immune system\", \"inflammation\", \"cardiovascular system\", \"central nervous system\", \"metabolism\", \"cancer\", and \"toxicology\". Only peer-reviewed articles written in English, with the full text available, have been included. Preclinical evidence has unraveled the P. notoginseng pharmacological effects in immune-inflammatory, cardiovascular, central nervous system, metabolic, and neoplastic diseases by acting on several molecular targets. However, few clinical studies have confirmed the therapeutic properties of P. notoginseng, mainly as an adjuvant in the conventional treatment of cardiovascular disorders. Further clinical studies, which both confirm the efficacy of P. notoginseng in free radical-related diseases and delve into its toxicological aspects, are mandatory to broaden its therapeutic potential.
摘要：
目前的证据表明，草药产品在自由基诱发的疾病中具有有益的作用。三七(伯克。)F.H.Chen长期以来在中医领域占据领先地位，促智,和抗应激活动，尽管这些属性在西方世界也得到承认。本文旨在综述三七的药理和毒理特性，并讨论其潜在的治疗作用。在Pubmed上进行了文献检索，Scopus,和Cochrane中央对照试验注册数据库。使用了以下搜索词:“三七”，“肠道微生物群”，“免疫系统”，\"炎症\",“心血管系统”，“中枢神经系统”，“新陈代谢”，\"癌症\",和“毒理学”。只有用英语写的同行评审文章，有了全文，已被包括在内。临床前证据揭示了三七在免疫炎症中的药理作用，心血管,中枢神经系统,新陈代谢，和肿瘤疾病通过作用于几个分子靶标。然而,很少有临床研究证实了三七的治疗特性，在心血管疾病的常规治疗中主要作为佐剂。进一步的临床研究，这既证实了三七在自由基相关疾病中的功效，又深入研究了其毒理学方面，是强制性的，以扩大其治疗潜力。
