PDF(Pubmed)
Abstract：
The pathogenesis of anorexia nervosa (AN) has been hypothesized to involve several biological systems. However, reliable biomarkers for AN have yet to be established. This study was aimed to identify statistically significant and clinically meaningful peripheral biomarkers associated with AN. A systematic literature search was conducted to identify studies published in English from inception until 30 June 2022. We conducted two-level random-effects meta-analyses to examine the difference between AN and comparison groups across 52 distinct biomarkers and found that acylated ghrelin, adrenocorticotropic hormone (ACTH), carboxy-terminal collagen crosslinks (CTX), cholesterol, cortisol, des-acyl ghrelin, ghrelin, growth hormone (GH), obestatin, and soluble leptin receptor levels were significantly higher in cases of AN compared with those in non-AN controls. Conversely, C-reactive protein (CRP), CD3 positive, CD8, creatinine, estradiol, follicle-stimulating hormone (FSH), free thyroxine, free triiodothyronine, glucose, insulin, insulin-like growth factor 1 (IGF-1), leptin, luteinizing hormone, lymphocyte, and prolactin levels were significantly lower in AN compared with those in non-AN controls. Our findings indicate that peripheral biomarkers may be linked to the pathophysiology of AN, such as processes of adaptation to starvation. Scientific investigation into peripheral biomarkers may ultimately yield breakthroughs in personalized clinical care for AN.
摘要：
据推测，神经性厌食症（AN）的发病机理涉及多个生物系统。然而,可靠的AN生物标志物尚未建立。本研究旨在鉴定与AN相关的具有统计学意义和临床意义的外周生物标志物。进行了系统的文献检索，以确定从开始到2022年6月30日以英语发表的研究。我们进行了两级随机效应荟萃分析，以检查在52种不同的生物标志物中AN和对照组之间的差异，发现酰化生长素释放肽，促肾上腺皮质激素（ACTH），羧基末端胶原交联（CTX），胆固醇,皮质醇,去酰基生长素释放肽，ghrelin,生长激素（GH），obestatin,与非AN对照相比，AN病例的可溶性瘦素受体水平显着升高。相反，C反应蛋白(CRP),CD3阳性,CD8，肌酐，雌二醇,卵泡刺激素（FSH），游离甲状腺素,游离三碘甲状腺原氨酸,葡萄糖，胰岛素，胰岛素样生长因子1（IGF-1），瘦素,黄体生成素,淋巴细胞，与非AN对照组相比，AN中的催乳素水平显着降低。我们的发现表明，外周生物标志物可能与AN的病理生理学有关，比如适应饥饿的过程。对外周生物标志物的科学研究可能最终在AN的个性化临床护理中取得突破。
