PDF(Pubmed)
Abstract：
Vitamin D3 deficiency and insufficiency are becoming a common global issue for us, especially in the most industrially developed countries. The only acknowledged activity of vitamin D3 in vertebrates is to promote the absorption of calcium and, therefore, allow for the mineralization of bones. Accordingly, its deficiency is associated with diseases such as rickets. Other numerous vital functions associated with vitamin D3 are yet to be considered, and the function of vitamin D2 in plants is unknown. Thus, 100 years after its discovery, the importance of vitamin D still seems to be unacknowledged (except for rickets), with little attention given to its decrease throughout the world. In this review, I suggest that vitamin D deficiency and insufficiency may be linked to the westernized lifestyle in more developed countries. Furthermore, I suggest that, rather than the calcemic activity, the main function of vitamin D is, in general, that of strengthening living organisms. I conclude with the hypothesis that vitamin D deficiency may represent a marker for a greater risk of chronic inflammatory diseases and a shorter life expectancy.
摘要：
维生素D3缺乏和不足正在成为我们共同的全球性问题，特别是在工业最发达的国家。维生素D3在脊椎动物中唯一公认的活性是促进钙的吸收，因此,允许骨骼的矿化。因此，它的缺乏与病等疾病有关。与维生素D3相关的其他许多重要功能尚未被考虑，维生素D2在植物中的功能是未知的。因此，它被发现100年后，维生素D的重要性似乎仍然没有得到承认（除了病），几乎没有注意到它在全世界的减少。在这次审查中,我认为维生素D缺乏和不足可能与更发达国家的西化生活方式有关。此外，我建议,而不是钙血活动，维生素D的主要功能是，总的来说,加强生物体。我得出的结论是，维生素D缺乏可能是慢性炎症性疾病风险更大和预期寿命更短的标志。
