PDF(Pubmed)
Abstract：
The prevalence of major bacterial infections has emerged as a significant menace to human health and life. Conventional treatment methods primarily rely on antibiotic therapy, but the overuse of these drugs has led to a decline in their efficacy. Moreover, bacteria have developed resistance towards antibiotics, giving rise to the emergence of superbugs. Consequently, there is an urgent need for novel antibacterial agents or alternative strategies to combat bacterial infections. Nanoantibiotics encompass a class of nano-antibacterial materials that possess inherent antimicrobial activity or can serve as carriers to enhance drug delivery efficiency and safety. In recent years, metal nanoclusters (M NCs) have gained prominence in the field of nanoantibiotics due to their ultra-small size (less than 3 nm) and distinctive electronic and optical properties, as well as their biosafety features. In this review, we discuss the recent progress of M NCs as a new generation of antibacterial agents. First, the main synthesis methods and characteristics of M NCs are presented. Then, we focus on reviewing various strategies for detecting and treating pathogenic bacterial infections using M NCs, summarizing the antibacterial effects of these nanoantibiotics on wound infections, biofilms, and oral infections. Finally, we propose a perspective on the remaining challenges and future developments of M NCs for bacterial infectious therapy.
摘要：
主要细菌感染的流行已成为对人类健康和生命的重大威胁。常规治疗方法主要依靠抗生素治疗,但是这些药物的过度使用导致其功效下降。此外，细菌对抗生素产生了抗药性，导致超级细菌的出现。因此,迫切需要新的抗菌剂或替代策略来对抗细菌感染。纳米抗生素包括一类具有固有抗微生物活性或可用作载体以增强药物递送效率和安全性的纳米抗菌材料。近年来,金属纳米团簇（MNCs）由于其超小尺寸（小于3nm）和独特的电子和光学性质，在纳米抗生素领域获得了突出的地位，以及它们的生物安全特征。在这次审查中,我们讨论了MNCs作为新一代抗菌剂的最新进展。首先,介绍了MNC的主要合成方法和特点。然后，我们专注于回顾使用MNC检测和治疗致病菌感染的各种策略，总结这些纳米抗生素对伤口感染的抗菌作用，生物膜，口腔感染。最后,我们提出了对MNCs用于细菌感染治疗的剩余挑战和未来发展的观点。
