PDF(Pubmed)
Abstract：
BACKGROUND: Neonatal and early-life gut microbiome changes are associated with altered cardiometabolic and immune development. In this study, we explored Cesarean delivery effects on the gut microbiome in our high-risk, under-resourced Bronx, NY population.
RESULTS: Fecal samples from the Bronx MomBa Health Study (Bronx MomBa Health Study) were categorized by delivery mode (vaginal/Cesarean) and analyzed via 16 S rRNA gene sequencing at four timepoints over the first two years of life. Bacteroidota organisms, which have been linked to decreased risk for obesity and type 2 diabetes, were relatively reduced by Cesarean delivery, while Firmicutes organisms were increased. Organisms belonging to the Enterococcus genus, which have been tied to aberrant immune cell development, were relatively increased in the Cesarean delivery microbiomes.
CONCLUSIONS: Due to their far-reaching impact on cardiometabolic and immune functions, Cesarean deliveries in high-risk patient populations should be carefully considered.
RESULTS: Fecal samples from the Bronx MomBa Health Study (Bronx MomBa Health Study) were categorized by delivery mode (vaginal/Cesarean) and analyzed via 16 S rRNA gene sequencing at four timepoints over the first two years of life. Bacteroidota organisms, which have been linked to decreased risk for obesity and type 2 diabetes, were relatively reduced by Cesarean delivery, while Firmicutes organisms were increased. Organisms belonging to the Enterococcus genus, which have been tied to aberrant immune cell development, were relatively increased in the Cesarean delivery microbiomes.
CONCLUSIONS: Due to their far-reaching impact on cardiometabolic and immune functions, Cesarean deliveries in high-risk patient populations should be carefully considered.
摘要：
背景：新生儿和早期肠道微生物组的变化与心脏代谢和免疫发育的改变有关。在这项研究中,我们探讨了剖宫产对高危人群肠道微生物组的影响，资源不足的布朗克斯,纽约人口。
结果：BronxMomBa健康研究（BronxMomBa健康研究）的粪便样本按分娩方式（阴道/剖宫产）进行分类，并通过16SrRNA基因测序在前四个时间点进行分析两年的生活。拟杆菌生物，这与肥胖和2型糖尿病的风险降低有关，剖腹产相对减少，而Firmicutes生物增加。属于肠球菌属的生物体，与异常的免疫细胞发育有关，剖宫产微生物组相对增加。
结论：由于它们对心脏代谢和免疫功能的深远影响，应仔细考虑高危患者人群的剖腹产。
结果：BronxMomBa健康研究（BronxMomBa健康研究）的粪便样本按分娩方式（阴道/剖宫产）进行分类，并通过16SrRNA基因测序在前四个时间点进行分析两年的生活。拟杆菌生物，这与肥胖和2型糖尿病的风险降低有关，剖腹产相对减少，而Firmicutes生物增加。属于肠球菌属的生物体，与异常的免疫细胞发育有关，剖宫产微生物组相对增加。
结论：由于它们对心脏代谢和免疫功能的深远影响，应仔细考虑高危患者人群的剖腹产。
