PDF(Pubmed)
Abstract：
Synapses are fundamental to the function of the central nervous system and are implicated in a number of brain disorders. Despite their pivotal role, a comprehensive imaging resource detailing the distribution of synapses in the human brain has been lacking until now. Here, we employ high-resolution PET neuroimaging in healthy humans (17F/16M) to create a 3D atlas of the synaptic marker Synaptic Vesicle glycoprotein 2A (SV2A). Calibration to absolute density values (pmol/ml) was achieved by leveraging postmortem human brain autoradiography data. The atlas unveils distinctive cortical and subcortical gradients of synapse density that reflect functional topography and hierarchical order from core sensory to higher-order integrative areas-a distribution that diverges from SV2A mRNA patterns. Furthermore, we found a positive association between IQ and SV2A density in several higher-order cortical areas. This new resource will help advance our understanding of brain physiology and the pathogenesis of brain disorders, serving as a pivotal tool for future neuroscience research.
摘要：
突触是中枢神经系统功能的基础，并且与许多脑部疾病有关。尽管发挥了关键作用,到目前为止，还缺乏详细说明人脑突触分布的全面成像资源。这里,我们在健康人(17F/16M)中使用高分辨率PET神经成像技术创建了突触标记突触小泡糖蛋白2A(SV2A)的3D图谱.通过利用死后人脑放射自显影数据来实现对绝对密度值(pmol/mL)的校准。图集揭示了突触密度的独特皮质和皮质下梯度，反映了从核心感觉到更高阶整合区域的功能形貌和层次顺序-这种分布与SV2AmRNA模式不同。此外，我们发现智商和SV2A密度在几个高阶皮质区域呈正相关.这一新资源将有助于提高我们对大脑生理学和大脑疾病发病机理的理解，作为未来神经科学研究的关键工具。这里的重要性陈述，我们提出了一个高分辨率的3D活体脑图谱，在人脑中的突触密度。在健康的人类大脑中，突触密度的独特皮质和皮质下梯度反映了从核心感觉区到高阶整合区的功能形貌和层次顺序-这种分布与SV2AmRNA模式不同。这本脑图集将有助于提高我们对人脑生理学和脑疾病发病机理的理解，作为未来临床研究的关键工具，翻译和比较神经科学。
