Abstract：
Evidence from epidemiological, clinical, and biological research resulted in the immune hypothesis: the hypothesis that immune system dysfunction is involved in the pathophysiology of schizophrenia spectrum disorders (SSD). The promising implication of this hypothesis is the potential to use existing immunomodulatory treatment for innovative interventions for SSD. Here, we provide a selective historical review of important discoveries that have shaped our understanding of immune dysfunction in SSD. We first explain the basic principles of immune dysfunction, after which we travel more than a century back in time. Starting our journey with neurosyphilis-associated psychosis in the nineteenth century, we continue by evaluating the role of infections and autoimmunity in SSD and findings from assessment of immune function using new techniques, such as cytokine levels, microglia density, neuroimaging, and gene expression. Drawing from these findings, we discuss anti-inflammatory interventions for SSD, and we conclude with a look into the future.
摘要：
流行病学证据,临床,和生物学研究产生了免疫假说:免疫系统功能障碍参与精神分裂症谱系障碍(SSD)的病理生理学的假说。该假设的有希望的含义是将现有的免疫调节治疗用于SSD的创新干预措施的潜力。这里,我们提供了对重要发现的选择性历史回顾，这些发现塑造了我们对SSD免疫功能障碍的理解。我们首先解释免疫功能障碍的基本原理，之后，我们回到了一个多世纪的时间。从19世纪神经梅毒相关精神病开始我们的旅程，我们继续评估感染和自身免疫在SSD中的作用，以及使用新技术评估免疫功能的结果，如细胞因子水平，小胶质细胞密度,神经影像学,和基因表达。根据这些发现，我们讨论了SSD的抗炎干预措施，最后我们展望一下未来.
