关键词: Alzheimer’s disease East Africa cognitive impairment dementia prevalence scoping review

Mesh : Humans Dementia / epidemiology Africa, Eastern / epidemiology Prevalence Cognitive Dysfunction / epidemiology Risk Factors Female Aged Male

来  源:   DOI:10.3233/JAD-240381

Abstract:
UNASSIGNED: Population-based research on the prevalence and determinants of dementia, Alzheimer\'s disease, and cognitive impairment is scarce in East Africa.
UNASSIGNED: To provide an overview of community- and population-based studies among older adults on the prevalence of dementia and cognitive impairment in East Africa, and identify research gaps.
UNASSIGNED: We carried out a literature search using three electronic databases (PubMed, Scopus, Google Scholar) using pertinent search terms.
UNASSIGNED: After screening 445 publications, we identified four publications on the population-based prevalence of dementia, and three on cognitive impairment. Prevalence rates varied from 6- 23% for dementia, and 7- 44% for cognitive impairment, among participants aged≥50-70 years. Old age and a lower education level were risk factors for dementia and cognitive impairment. Physical inactivity, lack of a ventilated kitchen, and history of central nervous system infections and chronic headache were associated with increased odds of dementia. Female sex, depression, having no spouse, increased lifetime alcohol consumption, low income, rural residence, and low family support were associated with increased odds of cognitive impairment. Potential misclassification and non-standardized data collection methods are research gaps that should be addressed in future studies.
UNASSIGNED: Establishing collaborative networks and partnering with international research institutions may enhance the capacity for conducting population-based studies on dementia and cognitive impairment in East Africa. Longitudinal studies may provide valuable insights on incidence, as well as potential risk and protective factors of dementia and cognitive impairment, and may inform the development of targeted interventions including preventive strategies in the region.
摘要:
关于痴呆症患病率和决定因素的基于人群的研究,老年痴呆症,在东非,认知障碍很少。
为了提供关于东非痴呆症和认知障碍患病率的老年人社区和人群研究的概述,并确定研究差距。
我们使用三个电子数据库(PubMed,Scopus,谷歌学者)使用相关的搜索词。
筛选445种出版物后,我们确定了四篇关于基于人群的痴呆症患病率的出版物,和三个关于认知障碍。痴呆症的患病率从6-23%不等,认知障碍占7-44%,在≥50-70岁的参与者中。老年和低教育水平是痴呆和认知障碍的危险因素。身体不活动,缺少通风厨房,中枢神经系统感染和慢性头痛的病史与痴呆的几率增加相关.女性性别,抑郁症,没有配偶,终身饮酒增加,低收入,农村住宅,家庭支持低与认知障碍的几率增加相关.潜在的错误分类和非标准化数据收集方法是研究空白,应在未来的研究中加以解决。
建立合作网络并与国际研究机构合作可能会增强在东非开展以人群为基础的痴呆症和认知障碍研究的能力。纵向研究可能为发病率提供有价值的见解,以及痴呆和认知障碍的潜在风险和保护因素,并可能为制定有针对性的干预措施提供信息,包括该地区的预防战略。
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