PDF(Pubmed)
Abstract：
UNASSIGNED: Conventional normative samples include individuals with undetected Alzheimer\'s disease neuropathology, lowering test sensitivity for cognitive impairment.
UNASSIGNED: We developed Mayo Normative Studies (MNS) norms limited to individuals without elevated amyloid or neurodegeneration (A-N-) for Rey\'s Auditory Verbal Learning Test (AVLT). We compared these MNS A-N- norms in female, male, and total samples to conventional MNS norms with varying levels of demographic adjustments.
UNASSIGNED: The A-N- sample included 1,059 Mayo Clinic Study of Aging cognitively unimpaired (CU) participants living in Olmsted County, MN, who are predominantly non-Hispanic White. Using a regression-based approach correcting for age, sex, and education, we derived fully-adjusted T-score formulas for AVLT variables. We validated these A-N- norms in two independent samples of CU (n = 261) and mild cognitive impairment (MCI)/dementia participants (n = 392) > 55 years of age.
UNASSIGNED: Variability associated with age decreased by almost half in the A-N- norm sample relative to the conventional norm sample. Fully-adjusted MNS A-N- norms showed approximately 7- 9% higher sensitivity to MCI/dementia compared to fully-adjusted MNS conventional norms for trials 1- 5 total and sum of trials. Among women, sensitivity to MCI/dementia increased with each normative data refinement. In contrast, age-adjusted conventional MNS norms showed greatest sensitivity to MCI/dementia in men.
UNASSIGNED: A-N- norms show some benefits over conventional normative approaches to MCI/dementia sensitivity, especially for women. We recommend using these MNS A-N- norms alongside MNS conventional norms. Future work is needed to determine if normative samples that are not well characterized clinically show greater benefit from biomarker-refined approaches.
UNASSIGNED: We developed Mayo Normative Studies (MNS) norms limited to individuals without elevated amyloid or neurodegeneration (A-N-) for Rey\'s Auditory Verbal Learning Test (AVLT). We compared these MNS A-N- norms in female, male, and total samples to conventional MNS norms with varying levels of demographic adjustments.
UNASSIGNED: The A-N- sample included 1,059 Mayo Clinic Study of Aging cognitively unimpaired (CU) participants living in Olmsted County, MN, who are predominantly non-Hispanic White. Using a regression-based approach correcting for age, sex, and education, we derived fully-adjusted T-score formulas for AVLT variables. We validated these A-N- norms in two independent samples of CU (n = 261) and mild cognitive impairment (MCI)/dementia participants (n = 392) > 55 years of age.
UNASSIGNED: Variability associated with age decreased by almost half in the A-N- norm sample relative to the conventional norm sample. Fully-adjusted MNS A-N- norms showed approximately 7- 9% higher sensitivity to MCI/dementia compared to fully-adjusted MNS conventional norms for trials 1- 5 total and sum of trials. Among women, sensitivity to MCI/dementia increased with each normative data refinement. In contrast, age-adjusted conventional MNS norms showed greatest sensitivity to MCI/dementia in men.
UNASSIGNED: A-N- norms show some benefits over conventional normative approaches to MCI/dementia sensitivity, especially for women. We recommend using these MNS A-N- norms alongside MNS conventional norms. Future work is needed to determine if normative samples that are not well characterized clinically show greater benefit from biomarker-refined approaches.
摘要：
■常规规范样本包括未发现阿尔茨海默病神经病理学的个体，降低认知障碍的测试敏感性。
■我们开发了Mayo规范研究（MNS）规范，仅限于没有淀粉样蛋白升高或神经变性（A-N-）的个体，用于Rey的听觉语言学习测试（AVLT）。我们比较了女性的这些MNSA-N-规范，男性,和总样本与传统MNS规范的人口统计调整水平不同。
■A-N-样本包括生活在奥姆斯特德县的1,059名梅奥诊所认知未受损（CU）参与者研究，MN,主要是非西班牙裔白人。使用基于回归的方法校正年龄，性别,和教育，我们推导了AVLT变量的完全调整T分数公式。我们在CU（n=261）和轻度认知障碍（MCI）/痴呆参与者（n=392）>55岁的两个独立样本中验证了这些A-N-范数。
■与年龄相关的变异性在A-N-范数样本中相对于常规范数样本减少了近一半。对于试验1-5总试验和总和,与完全调整MNS常规标准相比,完全调整的MNSA-N-标准对MCI/痴呆的敏感性高大约7-9%。在女性中,对MCI/痴呆的敏感性随着每个规范数据的细化而增加。相比之下,年龄校正的常规MNS标准显示男性对MCI/痴呆的敏感性最高.
■A-N-规范显示出对MCI/痴呆敏感性的常规规范方法有一些好处，尤其是对于女性。我们建议与MNS常规规范一起使用这些MNSA-N-规范。需要未来的工作来确定临床上没有很好表征的规范样品是否显示出更大的受益于生物标记物精炼方法。
■我们开发了Mayo规范研究（MNS）规范，仅限于没有淀粉样蛋白升高或神经变性（A-N-）的个体，用于Rey的听觉语言学习测试（AVLT）。我们比较了女性的这些MNSA-N-规范，男性,和总样本与传统MNS规范的人口统计调整水平不同。
■A-N-样本包括生活在奥姆斯特德县的1,059名梅奥诊所认知未受损（CU）参与者研究，MN,主要是非西班牙裔白人。使用基于回归的方法校正年龄，性别,和教育，我们推导了AVLT变量的完全调整T分数公式。我们在CU（n=261）和轻度认知障碍（MCI）/痴呆参与者（n=392）>55岁的两个独立样本中验证了这些A-N-范数。
■与年龄相关的变异性在A-N-范数样本中相对于常规范数样本减少了近一半。对于试验1-5总试验和总和,与完全调整MNS常规标准相比,完全调整的MNSA-N-标准对MCI/痴呆的敏感性高大约7-9%。在女性中,对MCI/痴呆的敏感性随着每个规范数据的细化而增加。相比之下,年龄校正的常规MNS标准显示男性对MCI/痴呆的敏感性最高.
■A-N-规范显示出对MCI/痴呆敏感性的常规规范方法有一些好处，尤其是对于女性。我们建议与MNS常规规范一起使用这些MNSA-N-规范。需要未来的工作来确定临床上没有很好表征的规范样品是否显示出更大的受益于生物标记物精炼方法。
