Abstract：
UNASSIGNED: Older adults with heart failure are at elevated risk of Alzheimer\'s disease and related dementias (AD/ADRD). Research suggests that insomnia and depressive episodes contribute somewhat dissociable impacts on risk for AD/ADRD in this patient population, although the temporal ordering of effects is unknown.
UNASSIGNED: This study examined time to dementia diagnosis among patients with comorbid insomnia and/or depressive episodes in an epidemiological sample.
UNASSIGNED: Secondary data analyses were conducted using a cohort study of 203,819 Veterans with a primary admission diagnosis of heart failure in 129 VA Medical Centers.
UNASSIGNED: Patients with diagnoses of both insomnia and depressive episodes had the shortest time to a dementia diagnosis at both 1-year (Hazard ratio = 1.43, 95% CI [1.36, 1.51]) and 3-year follow-up time points (Hazard ratio = 1.40, 95% CI [1.34, 1.47]) versus patients with one or neither comorbidity.
UNASSIGNED: Individuals with both comorbidities had the shortest time to dementia onset. Screening for these comorbidities may help to identify patients at elevated risk of dementia who could benefit from enhanced monitoring or early intervention strategies for more rapid detection and management of dementia symptoms.
UNASSIGNED: This study examined time to dementia diagnosis among patients with comorbid insomnia and/or depressive episodes in an epidemiological sample.
UNASSIGNED: Secondary data analyses were conducted using a cohort study of 203,819 Veterans with a primary admission diagnosis of heart failure in 129 VA Medical Centers.
UNASSIGNED: Patients with diagnoses of both insomnia and depressive episodes had the shortest time to a dementia diagnosis at both 1-year (Hazard ratio = 1.43, 95% CI [1.36, 1.51]) and 3-year follow-up time points (Hazard ratio = 1.40, 95% CI [1.34, 1.47]) versus patients with one or neither comorbidity.
UNASSIGNED: Individuals with both comorbidities had the shortest time to dementia onset. Screening for these comorbidities may help to identify patients at elevated risk of dementia who could benefit from enhanced monitoring or early intervention strategies for more rapid detection and management of dementia symptoms.
摘要：
■患有心力衰竭的老年人患阿尔茨海默病和相关痴呆（AD/ADRD）的风险升高。研究表明，失眠和抑郁发作对该患者人群的AD/ADRD风险有一定程度的影响。虽然影响的时间顺序是未知的。
■本研究调查了流行病学样本中合并失眠和/或抑郁发作患者的痴呆诊断时间。
■在129个VA医疗中心对203,819名主要入院诊断为心力衰竭的退伍军人进行了队列研究，进行了次要数据分析。
■诊断为失眠和抑郁发作的患者在1年（危险比=1.43，95％CI[1.36，1.51]）和3年随访时间点（危险比=1.40，95％CI[1.34，1.47]）诊断为痴呆的时间最短。
■患有两种合并症的人痴呆发作时间最短。筛查这些合并症可能有助于识别痴呆症风险升高的患者，这些患者可以从增强的监测或早期干预策略中受益，以更快地检测和管理痴呆症症状。
■本研究调查了流行病学样本中合并失眠和/或抑郁发作患者的痴呆诊断时间。
■在129个VA医疗中心对203,819名主要入院诊断为心力衰竭的退伍军人进行了队列研究，进行了次要数据分析。
■诊断为失眠和抑郁发作的患者在1年（危险比=1.43，95％CI[1.36，1.51]）和3年随访时间点（危险比=1.40，95％CI[1.34，1.47]）诊断为痴呆的时间最短。
■患有两种合并症的人痴呆发作时间最短。筛查这些合并症可能有助于识别痴呆症风险升高的患者，这些患者可以从增强的监测或早期干预策略中受益，以更快地检测和管理痴呆症症状。
