关键词: Alzheimer’s disease language mild cognitive impairment speech

Mesh : Humans Female Male Aged Cognitive Dysfunction / psychology diagnosis Aged, 80 and over Neuropsychological Tests Language Dementia / psychology Alzheimer Disease / psychology diagnosis Language Tests

来  源:   DOI:10.3233/JAD-230844

Abstract:
UNASSIGNED: Findings from language sample analyses can provide efficient and effective indicators of cognitive impairment in older adults.
UNASSIGNED: This study used newly automated core lexicon analyses of Cookie Theft picture descriptions to assess differences in typical use across three groups.
UNASSIGNED: Participants included adults without diagnosed cognitive impairments (Control), adults diagnosed with Alzheimer\'s disease (ProbableAD), and adults diagnosed with mild cognitive impairment (MCI). Cookie Theft picture descriptions were transcribed and analyzed using CLAN.
UNASSIGNED: Results showed that the ProbableAD group used significantly fewer core lexicon words overall than the MCI and Control groups. For core lexicon content words (nouns, verbs), however, both the MCI and ProbableAD groups produced significantly fewer words than the Control group. The groups did not differ in their use of core lexicon function words. The ProbableAD group was also slower to produce most of the core lexicon words than the MCI and Control groups. The MCI group was slower than the Control group for only two of the core lexicon content words. All groups mentioned a core lexicon word in the top left quadrant of the picture early in the description. The ProbableAD group was then significantly slower than the other groups to mention a core lexicon word in the other quadrants.
UNASSIGNED: This standard and simple-to-administer task reveals group differences in overall core lexicon scores and the amount of time until the speaker produces the key items. Clinicians and researchers can use these tools for both early assessment and measurement of change over time.
摘要:
来自语言样本分析的结果可以提供老年人认知障碍的有效指标。
本研究使用新的自动核心词典分析Cookie盗窃图片描述来评估三组典型使用的差异。
参与者包括未诊断为认知障碍的成年人(对照),被诊断患有阿尔茨海默病(ProbableAD)的成年人,和诊断为轻度认知障碍(MCI)的成年人。Cookie盗窃图片描述使用CLAN进行了转录和分析。
结果显示,与MCI和对照组相比,ProbableAD组总体上使用的核心词典单词明显减少。对于核心词典内容词(名词,动词),然而,MCI和ProbableAD组产生的单词明显少于对照组.这些小组在使用核心词典功能词方面没有差异。ProbableAD组比MCI和对照组产生大多数核心词典单词的速度也较慢。MCI组仅比对照组慢两个核心词典内容词。在描述的早期,所有小组都在图片的左上方象限中提到了一个核心词典单词。ProbableAD组在其他象限中提到核心词典单词的速度明显慢于其他组。
这项标准且易于管理的任务揭示了整体核心词典得分的群体差异以及演讲者产生关键项目的时间。临床医生和研究人员可以使用这些工具进行早期评估和随时间变化的测量。
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