Abstract：
Immature granulocytes (IGs) are used as markers of infection and systemic inflammation. We aimed to investigate the diagnostic value of IGs in children with urinary tract infections (UTIs). Children with their first UTIs were included in this observational study. Blood samples were obtained before antibiotic therapy. The blood analysis was repeated 2 weeks after the treatment ended. In total, 194 children (95 with febrile UTI, 58 with cystitis, and 41 controls) were included. The percentage of IGs (IG%) and IG count (IGC) measured at the time of admission were higher in the patients with febrile UTI than in the patients with cystitis and the controls (P = 0.000). The IGC and IG% after treatment were higher in patients with renal scarring than in those without scarring (P = 0.012 and P = 0.021, respectively). Cox\'s regression analysis showed the significant associations of renal scarring with both IGC and IG% (hazard ratio: 8.181, P = 0.002; hazard ratio: 5.106, P = 0.033, respectively). Both IGC and IG% were positively associated with severe vesicoureteral reflux (VUR) [odds ratio (OR): 22.235, P = 0.025; OR: 15.597, P = 0.038, respectively]. In conclusion, the IG% and IGC, which can be easily measured in a routine complete blood count without the need for additional effort, could be used as biomarkers for predicting febrile UTI, renal scarring, and severe VUR in children.
摘要：
未成熟粒细胞(IG)用作感染和全身性炎症的标志物。我们旨在探讨IGs在儿童尿路感染（UTI）中的诊断价值。首次尿路感染的儿童被纳入这项观察性研究。在抗生素治疗之前获得血液样品。在治疗结束后2周重复血液分析。总的来说,194名儿童(95名发热性尿路感染，58患有膀胱炎，和41个对照)被包括在内。高热UTI患者入院时的IGs百分比（IG％）和IG计数（IGC）高于膀胱炎患者和对照组（P=0.000）。有肾瘢痕的患者治疗后IGC和IG％高于无瘢痕的患者（分别为P=0.012和P=0.021）。Cox回归分析显示肾瘢痕形成与IGC和IG%显著相关(风险比:8.181,P=0.002;风险比:5.106,P=0.033)。IGC和IG％与严重膀胱输尿管反流（VUR）呈正相关[比值比（OR）：22.235，P=0.025；OR：15.597，P=0.038]。总之,IG%和IGC，这可以很容易地在常规全血细胞计数中测量，而不需要额外的努力，可作为预测发热尿路感染的生物标志物，肾瘢痕,和严重的VUR在儿童。
