PDF(Pubmed)
Abstract：
The basolateral amygdala plays pivotal roles in the regulation of fear and anxiety and these processes are profoundly modulated by different neuromodulatory systems that are recruited during emotional arousal. Recent studies suggest activities of BLA interneurons and inhibitory synaptic transmission in BLA principal cells are regulated by neuromodulators to influence the output and oscillatory network states of the BLA, and ultimately the behavioral expression of fear and anxiety. In this review, we first summarize a cellular mechanism of stress-induced anxiogenesis mediated by the interaction of glucocorticoid and endocannabinoid signaling at inhibitory synapses in the BLA. Then we discuss cell type-specific activity patterns induced by neuromodulators converging on the Gq signaling pathway in BLA perisomatic parvalbumin-expressing (PV) and cholecystokinin-expressing (CCK) basket cells and their effects on BLA network oscillations and fear learning.
摘要：
基底外侧杏仁核在调节恐惧和焦虑中起着关键作用，这些过程受到情绪唤醒期间招募的不同神经调节系统的深刻调节。最近的研究表明，BLA中间神经元的活动和BLA主细胞中的抑制性突触传递受神经调节剂的调节，以影响BLA的输出和振荡网络状态。最终是恐惧和焦虑的行为表达。在这次审查中,我们首先总结了BLA抑制性突触中糖皮质激素和内源性大麻素信号相互作用介导的应激诱导焦虑发生的细胞机制。然后，我们讨论了神经调节剂在BLA外周小白蛋白表达（PV）和胆囊收缩素表达（CCK）篮状细胞中聚集在Gq信号通路上诱导的细胞类型特异性活性模式及其对BLA网络振荡和恐惧学习的影响。
