PDF(Pubmed)
Abstract：
UNASSIGNED: We investigated the relationship between remnant cholesterol and carotid intraplaque neovascularization (IPN) assessed by contrast-enhanced ultrasonography (CEUS) in patients with ischemic stroke.
UNASSIGNED: This was a single-center study. Remnant cholesterol is calculated as total cholesterol minus low-density lipoprotein cholesterol (LDL-C) minus high-density lipoprotein cholesterol (HDL-C). All patients underwent CEUS. IPN is graded according to the presence and location of microbubbles within each plaque.
UNASSIGNED: The cohort included 110 patients with ischemic stroke. Patients with an IPN grading of 2 had higher triglyceride (TG), non-HDL-C, and remnant cholesterol concentrations than those with an IPN grading of < 2 (TG: 1.45 ± 0.69 vs. 0.96 ± 0.24 mmol/L, P < 0.001; non-HDL-C: 2.63 ± 0.85 vs. 2.31 ± 0.64 mmol/L, P = 0.037; remnant cholesterol: 0.57 ± 0.23 vs. 0.44 ± 0.07 mmol/L, P < 0.001). The multivariate-adjusted odds ratio (95% confidence interval) for remnant cholesterol was 27.728 (2.714 - 283.253) for an IPN grading of 2 in the subset of patients with an optimal LDL-C concentration.
UNASSIGNED: The remnant cholesterol concentration is significantly associated with carotid IPN on CEUS in patients with ischemic stroke with an optimal LDL-C concentration. Remnant cholesterol may be an important indicator of risk stratification in patients with ischemic stroke.
UNASSIGNED: This was a single-center study. Remnant cholesterol is calculated as total cholesterol minus low-density lipoprotein cholesterol (LDL-C) minus high-density lipoprotein cholesterol (HDL-C). All patients underwent CEUS. IPN is graded according to the presence and location of microbubbles within each plaque.
UNASSIGNED: The cohort included 110 patients with ischemic stroke. Patients with an IPN grading of 2 had higher triglyceride (TG), non-HDL-C, and remnant cholesterol concentrations than those with an IPN grading of < 2 (TG: 1.45 ± 0.69 vs. 0.96 ± 0.24 mmol/L, P < 0.001; non-HDL-C: 2.63 ± 0.85 vs. 2.31 ± 0.64 mmol/L, P = 0.037; remnant cholesterol: 0.57 ± 0.23 vs. 0.44 ± 0.07 mmol/L, P < 0.001). The multivariate-adjusted odds ratio (95% confidence interval) for remnant cholesterol was 27.728 (2.714 - 283.253) for an IPN grading of 2 in the subset of patients with an optimal LDL-C concentration.
UNASSIGNED: The remnant cholesterol concentration is significantly associated with carotid IPN on CEUS in patients with ischemic stroke with an optimal LDL-C concentration. Remnant cholesterol may be an important indicator of risk stratification in patients with ischemic stroke.
摘要：
■我们研究了缺血性卒中患者残余胆固醇与颈动脉斑块内新生血管形成（IPN）的关系。
■这是一项单中心研究。剩余胆固醇计算为总胆固醇减去低密度脂蛋白胆固醇（LDL-C）减去高密度脂蛋白胆固醇（HDL-C）。所有患者均接受CEUS检查。IPN根据每个斑块内微泡的存在和位置进行分级。
■该队列包括110例缺血性卒中患者。IPN分级为2的患者甘油三酯（TG）较高，非HDL-C,和残余胆固醇浓度比IPN等级<2的那些（TG：1.45±0.69vs.0.96±0.24mmol/L，P<0.001；非HDL-C：2.63±0.85vs.2.31±0.64mmol/L，P=0.037；残余胆固醇：0.57±0.23vs.0.44±0.07mmol/L，P<0.001)。在具有最佳LDL-C浓度的患者亚组中，对于IPN分级为2的患者，残余胆固醇的多变量校正比值比（95％置信区间）为27.728（2.714-283.253）。
■在具有最佳LDL-C浓度的缺血性中风患者中，残余胆固醇浓度与CEUS上的颈动脉IPN显着相关。残余胆固醇可能是缺血性卒中患者危险分层的重要指标。
■这是一项单中心研究。剩余胆固醇计算为总胆固醇减去低密度脂蛋白胆固醇（LDL-C）减去高密度脂蛋白胆固醇（HDL-C）。所有患者均接受CEUS检查。IPN根据每个斑块内微泡的存在和位置进行分级。
■该队列包括110例缺血性卒中患者。IPN分级为2的患者甘油三酯（TG）较高，非HDL-C,和残余胆固醇浓度比IPN等级<2的那些（TG：1.45±0.69vs.0.96±0.24mmol/L，P<0.001；非HDL-C：2.63±0.85vs.2.31±0.64mmol/L，P=0.037；残余胆固醇：0.57±0.23vs.0.44±0.07mmol/L，P<0.001)。在具有最佳LDL-C浓度的患者亚组中，对于IPN分级为2的患者，残余胆固醇的多变量校正比值比（95％置信区间）为27.728（2.714-283.253）。
■在具有最佳LDL-C浓度的缺血性中风患者中，残余胆固醇浓度与CEUS上的颈动脉IPN显着相关。残余胆固醇可能是缺血性卒中患者危险分层的重要指标。
