UNASSIGNED: This was a single-center study. Remnant cholesterol is calculated as total cholesterol minus low-density lipoprotein cholesterol (LDL-C) minus high-density lipoprotein cholesterol (HDL-C). All patients underwent CEUS. IPN is graded according to the presence and location of microbubbles within each plaque.
UNASSIGNED: The cohort included 110 patients with ischemic stroke. Patients with an IPN grading of 2 had higher triglyceride (TG), non-HDL-C, and remnant cholesterol concentrations than those with an IPN grading of < 2 (TG: 1.45 ± 0.69 vs. 0.96 ± 0.24 mmol/L, P < 0.001; non-HDL-C: 2.63 ± 0.85 vs. 2.31 ± 0.64 mmol/L, P = 0.037; remnant cholesterol: 0.57 ± 0.23 vs. 0.44 ± 0.07 mmol/L, P < 0.001). The multivariate-adjusted odds ratio (95% confidence interval) for remnant cholesterol was 27.728 (2.714 - 283.253) for an IPN grading of 2 in the subset of patients with an optimal LDL-C concentration.
UNASSIGNED: The remnant cholesterol concentration is significantly associated with carotid IPN on CEUS in patients with ischemic stroke with an optimal LDL-C concentration. Remnant cholesterol may be an important indicator of risk stratification in patients with ischemic stroke.
■这是一项单中心研究。剩余胆固醇计算为总胆固醇减去低密度脂蛋白胆固醇(LDL-C)减去高密度脂蛋白胆固醇(HDL-C)。所有患者均接受CEUS检查。IPN根据每个斑块内微泡的存在和位置进行分级。
■该队列包括110例缺血性卒中患者。IPN分级为2的患者甘油三酯(TG)较高,非HDL-C,和残余胆固醇浓度比IPN等级<2的那些(TG:1.45±0.69vs.0.96±0.24mmol/L,P<0.001;非HDL-C:2.63±0.85vs.2.31±0.64mmol/L,P=0.037;残余胆固醇:0.57±0.23vs.0.44±0.07mmol/L,P<0.001)。在具有最佳LDL-C浓度的患者亚组中,对于IPN分级为2的患者,残余胆固醇的多变量校正比值比(95%置信区间)为27.728(2.714-283.253)。
■在具有最佳LDL-C浓度的缺血性中风患者中,残余胆固醇浓度与CEUS上的颈动脉IPN显着相关。残余胆固醇可能是缺血性卒中患者危险分层的重要指标。