PDF(Pubmed)
Abstract：
UNASSIGNED: miRNAs are small, conserved, single-stranded non-coding RNA that are typically transported by exosomes for their functional roles. The therapeutic potential of exosomal miRNAs has been explored in various diseases including breast cancer, pancreatic cancer, cholangiocarcinoma, skin diseases, Alzheimer\'s disease, stroke, and glioma. Pathophysiological processes such as cellular inflammation, apoptosis, necrosis, immune dysfunction, and oxidative stress are closely associated with miRNAs. Internal and external factors such as tissue ischemia, hypoxia, pathogen infection, and endotoxin exposure can trigger these reactions and are linked to miRNAs. Paraquat-induced fibrosis is a protracted process that may not manifest immediately after injury but develops during bodily recovery, providing insights into potential miRNA intervention treatments.
UNASSIGNED: These findings could potentially be applied for further pharmaceutical research and clinical therapy of paraquat-induced pulmonary fibrosis, and are likely to be of great interest to clinicians involved in lung fibrosis research.
UNASSIGNED: Through a literature review, we identified an association between miR-15a-5p and miR-152-3p and their involvement in the Wnt signaling pathway. This allowed us to deduce the molecular mechanisms underlying regulatory interactions involved in paraquat-induced lung fibrosis.
UNASSIGNED: miR-15a-5p and miR-152-3p play roles in body repair processes, and pulmonary fibrosis can be considered a form of reparative response by the body. Although the initial purpose of fibrotic repair is to restore normal body function, excessive tissue fibrosis, unlike scar formation following external skin trauma, can significantly and adversely affect the body. Modulating the Wnt/β-catenin signaling pathway is beneficial in alleviating tissue fibrosis in various diseases.
UNASSIGNED: In this study, we delineate the association between miR-15a-5p and miR-152-3p and the Wnt/β-catenin signaling pathway, presenting a novel concept for addressing paraquat-induced pulmonary fibrosis.
UNASSIGNED: These findings could potentially be applied for further pharmaceutical research and clinical therapy of paraquat-induced pulmonary fibrosis, and are likely to be of great interest to clinicians involved in lung fibrosis research.
UNASSIGNED: Through a literature review, we identified an association between miR-15a-5p and miR-152-3p and their involvement in the Wnt signaling pathway. This allowed us to deduce the molecular mechanisms underlying regulatory interactions involved in paraquat-induced lung fibrosis.
UNASSIGNED: miR-15a-5p and miR-152-3p play roles in body repair processes, and pulmonary fibrosis can be considered a form of reparative response by the body. Although the initial purpose of fibrotic repair is to restore normal body function, excessive tissue fibrosis, unlike scar formation following external skin trauma, can significantly and adversely affect the body. Modulating the Wnt/β-catenin signaling pathway is beneficial in alleviating tissue fibrosis in various diseases.
UNASSIGNED: In this study, we delineate the association between miR-15a-5p and miR-152-3p and the Wnt/β-catenin signaling pathway, presenting a novel concept for addressing paraquat-induced pulmonary fibrosis.
摘要：
■miRNA很小，保守的，单链非编码RNA，通常由外泌体转运，以发挥其功能作用。外泌体miRNAs的治疗潜力已经在包括乳腺癌在内的各种疾病中被探索。胰腺癌,胆管癌,皮肤病,老年痴呆症,中风,还有神经胶质瘤.病理生理过程，如细胞炎症，凋亡，坏死,免疫功能障碍，氧化应激与miRNAs密切相关。内部和外部因素，如组织缺血，缺氧,病原体感染,内毒素暴露可以触发这些反应，并与miRNA相关。百草枯诱导的纤维化是一个长期的过程，可能不会在受伤后立即显现，但在身体恢复期间发展。提供潜在的miRNA干预治疗的见解。
■这些发现有可能应用于百草枯引起的肺纤维化的进一步药物研究和临床治疗，并且可能对参与肺纤维化研究的临床医生非常感兴趣。
■通过文献综述，我们发现miR-15a-5p和miR-152-3p与Wnt信号通路相关.这使我们能够推断出百草枯诱导的肺纤维化中涉及的调节相互作用的分子机制。
■miR-15a-5p和miR-152-3p在身体修复过程中发挥作用，肺纤维化可以被认为是身体的一种修复反应。虽然纤维化修复的最初目的是恢复正常的身体功能，过度的组织纤维化，与外部皮肤创伤后的疤痕形成不同，可以显著和不利地影响身体。调节Wnt/β-catenin信号通路有利于减轻各种疾病中的组织纤维化。
■在这项研究中，我们描述了miR-15a-5p和miR-152-3p与Wnt/β-catenin信号通路之间的关联,提出了解决百草枯引起的肺纤维化的新概念。
■这些发现有可能应用于百草枯引起的肺纤维化的进一步药物研究和临床治疗，并且可能对参与肺纤维化研究的临床医生非常感兴趣。
■通过文献综述，我们发现miR-15a-5p和miR-152-3p与Wnt信号通路相关.这使我们能够推断出百草枯诱导的肺纤维化中涉及的调节相互作用的分子机制。
■miR-15a-5p和miR-152-3p在身体修复过程中发挥作用，肺纤维化可以被认为是身体的一种修复反应。虽然纤维化修复的最初目的是恢复正常的身体功能，过度的组织纤维化，与外部皮肤创伤后的疤痕形成不同，可以显著和不利地影响身体。调节Wnt/β-catenin信号通路有利于减轻各种疾病中的组织纤维化。
■在这项研究中，我们描述了miR-15a-5p和miR-152-3p与Wnt/β-catenin信号通路之间的关联,提出了解决百草枯引起的肺纤维化的新概念。
