PDF(Pubmed)
Abstract：
In this pilot study, the authors investigated the preliminary effectiveness of the digital lifestyle intervention, actensio (mementor DE GmbH), in treating arterial hypertension. Adults with arterial hypertension were randomly assigned to an intervention group (actensio + standard care) or a control group (waiting list + standard care) in a 1:1 ratio. Primary and secondary endpoints were assessed at baseline (t0) and 3 months post-randomization (t1). The primary endpoint was average systolic blood pressure, measured at home for 1 week. Secondary endpoints included patient engagement (measured using the \"patient activation measure\"; PAM-13), average diastolic blood pressure, and heart rate. All endpoints were analyzed using ANCOVA models, following an intention-to-treat approach, while adjusting for baseline values. Missing data were estimated using multiple imputation models. A total of N = 102 participants (f = 59, age = 52.94 ± 9.01) were randomized to either the intervention (IG; N = 52) or the control group (CG; N = 50), of which N = 80 completed the blood pressure diary, and N = 81 the PAM-13 at t1. Between-group comparisons showed an average group difference in systolic blood pressure of -5.06 mm Hg (95% CI = -8.71 to -1.41, p = .013) between the intervention group (M = 137.37 ± 10.13) and the control group (M = 142.35 ± 11.23). Average group difference for patient engagement was 3.35 points with a trend towards statistical significance (95% CI = -018 to 6.89, p = .064), favoring the intervention group (MIG = 79.38 ± 9.44 vs. MCG = 75.45 ± 10.62). There were no group differences in diastolic blood pressure (-1.78 mm Hg; 95% CI = -4.50 to 0.95, p = .402) and heart rate (-0.684; 95% CI = -3.73 to 2.36, p = 0.683). The results of the present pilot study confirm the preliminary effectiveness of the digital lifestyle intervention, actensio, in reducing high blood pressure in patients with hypertension.
摘要：
在这项试点研究中，作者调查了数字生活方式干预的初步有效性，actensio(mementorDEGmbH)，治疗动脉高血压。患有动脉高血压的成年人以1：1的比例随机分配到干预组（actensio标准护理）或对照组（等待名单标准护理）。在基线（t0）和随机化后3个月（t1）评估主要和次要终点。主要终点是平均收缩压，在家测量1周。次要终点包括患者参与(使用“患者激活测量”；PAM-13测量)，平均舒张压,和心率。使用ANCOVA模型分析所有终点，遵循意向治疗方法，同时调整基线值。使用多个插补模型估计缺失数据。总共N=102名参与者（f=59，年龄=52.94±9.01）被随机分为干预组（IG;N=52）或对照组（CG;N=50），其中N=80完成了血压日记，和N=81的PAM-13在t1。组间比较显示，干预组（M=137.37±10.13）和对照组（M=142.35±11.23）之间收缩压的平均组间差异为-5.06mmHg（95％CI=-8.71至-1.41，p=.013）。患者参与的平均组差异为3.35分，具有统计学意义的趋势（95％CI=-018至6.89，p=.064），有利于干预组(MIG=79.38±9.44vs.MCG=75.45±10.62)。舒张压（-1.78mmHg；95％CI=-4.50至0.95，p=.402）和心率（-0.684；95％CI=-3.73至2.36，p=0.683）没有组间差异。本试点研究的结果证实了数字生活方式干预的初步有效性，actensio,降低高血压患者的高血压。
