Abstract：
OBJECTIVE: To examine the prevalence of overactive bladder (OAB) according to menopausal stages in middle-aged women.
METHODS: Cross-sectional study.
METHODS: Total Healthcare Center in South Korea.
METHODS: Middle-aged Korean women (n=3469, mean age, 49.5 ± 2.9 years).
METHODS: Menopausal stages were defined according to the Stages of Reproductive Aging Workshop +10 criteria, and menopausal symptoms were assessed using the Korean version of Menopause-Specific Quality of Life (MENQOL). Logistic regression models were used to estimate prevalence ratios with 95% confidence intervals for OAB according to menopausal stage and to assess the associations with menopausal symptoms.
METHODS: OAB symptoms were evaluated using the Overactive Bladder Symptom Score (OABSS).
RESULTS: The prevalence of OAB increased with menopausal stage; however, the multivariable-adjusted prevalence ratios for women in menopausal transition and postmenopausal stage were insignificant (ptrend = 0.160) compared to those for premenopausal women. Among individual OAB symptoms, the multivariable-adjusted prevalence ratios for nocturia increased with menopausal stage in a dose-response manner (ptrend = 0.005 for 1 time/day; ptrend < 0.001 for ≥2 times/day). The association between menopausal stages and nocturia occurring ≥2 times/day was evident in women without OAB and with relatively high MENQOL scores, vasomotor symptoms and difficulty sleeping.
CONCLUSIONS: The prevalence of OAB, particularly nocturia, increased with menopausal stage, and the association was obvious in women with other menopausal symptoms. This finding underscores the importance of addressing nocturia as a potential menopausal symptom in middle-aged women. Further studies are required to understand the mechanisms linking OAB with menopausal symptoms in middle-aged women.
METHODS: Cross-sectional study.
METHODS: Total Healthcare Center in South Korea.
METHODS: Middle-aged Korean women (n=3469, mean age, 49.5 ± 2.9 years).
METHODS: Menopausal stages were defined according to the Stages of Reproductive Aging Workshop +10 criteria, and menopausal symptoms were assessed using the Korean version of Menopause-Specific Quality of Life (MENQOL). Logistic regression models were used to estimate prevalence ratios with 95% confidence intervals for OAB according to menopausal stage and to assess the associations with menopausal symptoms.
METHODS: OAB symptoms were evaluated using the Overactive Bladder Symptom Score (OABSS).
RESULTS: The prevalence of OAB increased with menopausal stage; however, the multivariable-adjusted prevalence ratios for women in menopausal transition and postmenopausal stage were insignificant (ptrend = 0.160) compared to those for premenopausal women. Among individual OAB symptoms, the multivariable-adjusted prevalence ratios for nocturia increased with menopausal stage in a dose-response manner (ptrend = 0.005 for 1 time/day; ptrend < 0.001 for ≥2 times/day). The association between menopausal stages and nocturia occurring ≥2 times/day was evident in women without OAB and with relatively high MENQOL scores, vasomotor symptoms and difficulty sleeping.
CONCLUSIONS: The prevalence of OAB, particularly nocturia, increased with menopausal stage, and the association was obvious in women with other menopausal symptoms. This finding underscores the importance of addressing nocturia as a potential menopausal symptom in middle-aged women. Further studies are required to understand the mechanisms linking OAB with menopausal symptoms in middle-aged women.
摘要：
目的：根据绝经阶段了解中年女性膀胱过度活动症（OAB）的患病率。
方法：横断面研究。
方法：韩国总医疗中心。
方法：中年韩国女性（n=3469，平均年龄，49.5±2.9年）。
方法：根据生殖衰老研讨会的阶段+10个标准定义更年期阶段，和更年期症状使用韩国版本的更年期特异性生活质量(MENQOL)进行评估。根据绝经阶段，使用Logistic回归模型以95％置信区间估算OAB的患病率，并评估与绝经症状的关联。
方法：使用膀胱过度活动症状评分（OABSS）评估OAB症状。
结果：OAB的患病率随着绝经阶段而增加；然而，与绝经前女性相比,绝经过渡期和绝经后女性的多变量校正患病率不显著(ptrend=0.160).在个别OAB症状中，多变量校正后的夜尿症患病率随着绝经期以剂量-反应方式增加(1次/天ptrend=0.005;≥2次/天ptrend<0.001).在无OAB且MENQOL评分相对较高的女性中，更年期与夜尿症发生≥2次/天之间的关联很明显，血管舒缩症状和睡眠困难。
结论：OAB的患病率，尤其是夜尿症,随着更年期增加，在有其他更年期症状的女性中，这种关联是明显的。这一发现强调了将夜尿症作为中年女性潜在的更年期症状的重要性。需要进一步的研究来了解将OAB与中年女性更年期症状联系起来的机制。
方法：横断面研究。
方法：韩国总医疗中心。
方法：中年韩国女性（n=3469，平均年龄，49.5±2.9年）。
方法：根据生殖衰老研讨会的阶段+10个标准定义更年期阶段，和更年期症状使用韩国版本的更年期特异性生活质量(MENQOL)进行评估。根据绝经阶段，使用Logistic回归模型以95％置信区间估算OAB的患病率，并评估与绝经症状的关联。
方法：使用膀胱过度活动症状评分（OABSS）评估OAB症状。
结果：OAB的患病率随着绝经阶段而增加；然而，与绝经前女性相比,绝经过渡期和绝经后女性的多变量校正患病率不显著(ptrend=0.160).在个别OAB症状中，多变量校正后的夜尿症患病率随着绝经期以剂量-反应方式增加(1次/天ptrend=0.005;≥2次/天ptrend<0.001).在无OAB且MENQOL评分相对较高的女性中，更年期与夜尿症发生≥2次/天之间的关联很明显，血管舒缩症状和睡眠困难。
结论：OAB的患病率，尤其是夜尿症,随着更年期增加，在有其他更年期症状的女性中，这种关联是明显的。这一发现强调了将夜尿症作为中年女性潜在的更年期症状的重要性。需要进一步的研究来了解将OAB与中年女性更年期症状联系起来的机制。
