{Reference Type}: Journal Article
{Title}: Menopausal stages and overactive bladder symptoms in middle-aged women: A cross-sectional study.
{Author}: Park J;Chang Y;Kim JH;Choi HR;Kwon R;Lim GY;Ahn J;Kim KH;Kim H;Hong YS;Zhao D;Cho J;Guallar E;Park HY;Ryu S;
{Journal}: BJOG
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 11
{Factor}: 7.331
{DOI}: 10.1111/1471-0528.17912
{Abstract}: <B>OBJECTIVE: </B>To examine the prevalence of overactive bladder (OAB) according to menopausal stages in middle-aged women.<BR><B>METHODS: </B>Cross-sectional study.<BR><B>METHODS: </B>Total Healthcare Center in South Korea.<BR><B>METHODS: </B>Middle-aged Korean women (n=3469, mean age, 49.5 ± 2.9 years).<BR><B>METHODS: </B>Menopausal stages were defined according to the Stages of Reproductive Aging Workshop +10 criteria, and menopausal symptoms were assessed using the Korean version of Menopause-Specific Quality of Life (MENQOL). Logistic regression models were used to estimate prevalence ratios with 95% confidence intervals for OAB according to menopausal stage and to assess the associations with menopausal symptoms.<BR><B>METHODS: </B>OAB symptoms were evaluated using the Overactive Bladder Symptom Score (OABSS).<BR><B>RESULTS: </B>The prevalence of OAB increased with menopausal stage; however, the multivariable-adjusted prevalence ratios for women in menopausal transition and postmenopausal stage were insignificant (ptrend = 0.160) compared to those for premenopausal women. Among individual OAB symptoms, the multivariable-adjusted prevalence ratios for nocturia increased with menopausal stage in a dose-response manner (ptrend = 0.005 for 1 time/day; ptrend < 0.001 for ≥2 times/day). The association between menopausal stages and nocturia occurring ≥2 times/day was evident in women without OAB and with relatively high MENQOL scores, vasomotor symptoms and difficulty sleeping.<BR><B>CONCLUSIONS: </B>The prevalence of OAB, particularly nocturia, increased with menopausal stage, and the association was obvious in women with other menopausal symptoms. This finding underscores the importance of addressing nocturia as a potential menopausal symptom in middle-aged women. Further studies are required to understand the mechanisms linking OAB with menopausal symptoms in middle-aged women.