■阻塞性睡眠呼吸暂停(OSA)是夜尿症的病因之一。我们分析了多导睡眠图(PSG)结果,以确定与不同严重程度的OSA患者夜尿症相关的因素。
■使用PSG检查疑似OSA的患者。根据夜尿症的存在将它们分为两组。夜尿症被定义为需要至少排泄一次的患者。采用呼吸暂停低通气指数(AHI)根据严重程度对患者进行分类:AHI<5次事件/h,5个事件/h≤AHI<15个事件/h,15个事件/h≤AHI<30个事件/h,AHI≥30个事件/h,定义为正常,轻度OSA,中度OSA,和严重的OSA,分别。人口统计变量,PSG参数,国际前列腺症状评分(IPSS)并对泌尿系症状引起的生活质量评分进行分析。
■在总共140名患者中,114名患者患有OSA(48名患有轻度OSA;34名患有中度OSA;32名患有重度OSA),107名患者患有夜尿症。除重度OSA患者组外,所有组夜尿症患者的总IPSS均显着较高。随着OSA严重程度的增加,确定了更多与夜尿症相关的因素。轻度OSA患者,夜尿症与年龄增加有关(p=0.025),最低动脉血氧合饱和度(p=0.046),非快速眼动的AHI降低(p=0.047),总睡眠时间的AHI(p=0.010),和去饱和指数(p=0.012)。在中度OSA患者中,夜尿症与年龄增长有关(p<0.001),清醒时间(p=0.025),第一阶段睡眠(p=0.033),和睡眠延迟(p=0.033),高度降低(p=0.044),重量(p=0.025),和睡眠效率(p=0.003)。在重度OSA患者中,夜尿症与体重增加有关(p=0.011),体重指数(p=0.009),清醒时间(p=0.008),第一阶段睡眠(p=0.040),唤醒数(p=0.030),唤醒指数(p=0.013),周期性肢体运动数(p=0.013),和周期性肢体运动指数(p=0.004),基线动脉血氧合饱和度降低(p=0.046)。
■我们的研究表明,随着OSA严重程度的增加,与夜尿症相关的因素更多。本研究有助于不同严重程度OSA患者的临床教育和治疗。
UNASSIGNED: Obstructive sleep apnea (OSA) is one of the etiologies of
nocturia. We analyzed polysomnography (PSG) results to determine correlated factors related to
nocturia in OSA patients with different severity.
UNASSIGNED: Patients with suspected OSA were examined using PSG. They were divided into two groups based on the presence of
nocturia.
Nocturia was defined as a patient who needed to void at least once. Apnea-hypopnea index (AHI) was employed to classify patients according to degrees of severity: AHI<5 events/h, 5 events/h≤AHI<15 events/h, 15 events/h≤AHI<30 events/h, and AHI≥30 events/h, defined as normal, mild OSA, moderate OSA, and severe OSA, respectively. Demographic variables, PSG parameters, International Prostate Symptom Scores (IPSSs), and quality of life scores due to urinary symptoms were analyzed.
UNASSIGNED: In total 140 patients, 114 patients had OSA (48 had mild OSA; 34 had moderate OSA; and 32 had severe OSA) and 107 patients had nocturia. The total IPSS was significantly higher in nocturia patients in all groups except the group of severe OSA patients. With the increasing severity of OSA, more correlated factors related to
nocturia were determined. In mild OSA patients, nocturia related to increased age (p=0.025), minimum arterial blood oxygenation saturation (p=0.046), and decreased AHI of non-rapid eye movement (p=0.047), AHI of total sleep time (p=0.010), and desaturation index (p=0.012). In moderate OSA patients, nocturia related to increased age (p<0.001), awake time (p=0.025), stage 1 sleep (p=0.033), and sleep latency (p=0.033), and decreased height (p=0.044), weight (p=0.025), and sleep efficiency (p=0.003). In severe OSA patients, nocturia related to increased weight (p=0.011), body mass index (p=0.009), awake time (p=0.008), stage 1 sleep (p=0.040), arousal number (p=0.030), arousal index (p=0.013), periodic limb movement number (p=0.013), and periodic limb movement index (p=0.004), and decreased baseline arterial blood oxygenation saturation (p=0.046).
UNASSIGNED: Our study revealed that there were more correlated factors related to nocturia with increasing severity of OSA. This study helps in clinical education and treatment for OSA patients with different severity.