Abstract：
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease of unknown etiology. The aim of this study was to evaluate the environmental and occupational risk factors of IPF.
METHODS: This hospital-based, case-control study included 206 patients with IPF selected from the Seoul National University Bundang Hospital Interstitial Lung Disease registry and 167 controls without lung disease. Data on occupation, lifestyle, transportation, and types of environmental and occupational dust exposure were obtained using a questionnaire. IPF diagnosis was confirmed based on the recent guidelines, and the possibility of hypersensitivity pneumonitis was excluded. Multiple logistic regression was performed to determine the risk factors for IPF.
RESULTS: After adjusting for age and sex, ever-smokers (odds ratio [OR], 2.35; 95 % confidence interval [CI]: 1.51-3.68) and individuals who smoked more than 30 pack-years (OR, 2.79; 95%CI: 1.70-4.68) showed an increased risk for IPF. Any occupational dust exposure (adjusted OR, 2.08; 95%CI: 1.19-3.72), especially exposure to chemicals (adjusted OR, 3.52; 99%CI: 1.56-9.05), was associated with IPF after adjusting for age, sex, and smoking.
CONCLUSIONS: Smoking and occupational dust exposure are associated with an increased risk for IPF. Both factors have dose and duration-dependent relationships with the risk for IPF.
METHODS: This hospital-based, case-control study included 206 patients with IPF selected from the Seoul National University Bundang Hospital Interstitial Lung Disease registry and 167 controls without lung disease. Data on occupation, lifestyle, transportation, and types of environmental and occupational dust exposure were obtained using a questionnaire. IPF diagnosis was confirmed based on the recent guidelines, and the possibility of hypersensitivity pneumonitis was excluded. Multiple logistic regression was performed to determine the risk factors for IPF.
RESULTS: After adjusting for age and sex, ever-smokers (odds ratio [OR], 2.35; 95 % confidence interval [CI]: 1.51-3.68) and individuals who smoked more than 30 pack-years (OR, 2.79; 95%CI: 1.70-4.68) showed an increased risk for IPF. Any occupational dust exposure (adjusted OR, 2.08; 95%CI: 1.19-3.72), especially exposure to chemicals (adjusted OR, 3.52; 99%CI: 1.56-9.05), was associated with IPF after adjusting for age, sex, and smoking.
CONCLUSIONS: Smoking and occupational dust exposure are associated with an increased risk for IPF. Both factors have dose and duration-dependent relationships with the risk for IPF.
摘要：
背景：特发性肺纤维化（IPF）是一种病因不明的进行性间质性肺病。这项研究的目的是评估IPF的环境和职业危险因素。
方法：这家以医院为基础的，病例对照研究纳入了从首尔国立大学Bundang医院间质性肺病登记处选择的206例IPF患者和167例无肺病对照.职业数据，生活方式,交通运输,并通过问卷调查获得了环境和职业粉尘暴露的类型。根据最近的指南确认了IPF的诊断，并排除了过敏性肺炎的可能性.采用多因素logistic回归分析IPF的危险因素。
结果：在调整了年龄和性别之后，曾经吸烟者(赔率比[OR]，2.35；95%置信区间[CI]：1.51-3.68)和吸烟超过30包年的个体(OR，2.79；95CI：1.70-4.68）显示IPF风险增加。任何职业粉尘暴露(调整或,2.08；95CI：1.19-3.72），尤其是接触化学品(调整后的OR，3.52；99CI：1.56-9.05），在调整年龄后与IPF相关，性别,和吸烟。
结论：吸烟和职业粉尘暴露与IPF风险增加相关。这两个因素与IPF的风险具有剂量和持续时间依赖性关系。
方法：这家以医院为基础的，病例对照研究纳入了从首尔国立大学Bundang医院间质性肺病登记处选择的206例IPF患者和167例无肺病对照.职业数据，生活方式,交通运输,并通过问卷调查获得了环境和职业粉尘暴露的类型。根据最近的指南确认了IPF的诊断，并排除了过敏性肺炎的可能性.采用多因素logistic回归分析IPF的危险因素。
结果：在调整了年龄和性别之后，曾经吸烟者(赔率比[OR]，2.35；95%置信区间[CI]：1.51-3.68)和吸烟超过30包年的个体(OR，2.79；95CI：1.70-4.68）显示IPF风险增加。任何职业粉尘暴露(调整或,2.08；95CI：1.19-3.72），尤其是接触化学品(调整后的OR，3.52；99CI：1.56-9.05），在调整年龄后与IPF相关，性别,和吸烟。
结论：吸烟和职业粉尘暴露与IPF风险增加相关。这两个因素与IPF的风险具有剂量和持续时间依赖性关系。
