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Abstract：
BACKGROUND: Sarcopenia is a common cause of disability in the aging population, and managing sarcopenia is an important step in building intrinsic capacity and promoting healthy aging. A growing body of evidence suggests that sleep deprivation may be a mediator of the development of sarcopenia. The purpose of this study was to explore the longitudinal association between sleep duration and possible sarcopenia using data from a national sample.
METHODS: Two waves of data from the CHARLS database for 2011 and 2015 were used in this study. All possible sarcopenia participants met the Asia Working Group for Sarcopenia 2019 (AWGS 2019) diagnostic criteria. Sleep duration was assessed using a self-report questionnaire, and sleep duration was categorized as short (≤ 6 h), medium (6-8 h), or long (> 8 h) based on previous studies. Longitudinal associations between sleep duration and possible sarcopenia will be calculated by univariate and multifactorial logistic regression analyses and expressed as odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS: A total of 5654 individuals participated in the follow-up study, with a prevalence of possible sarcopenia of 53.72% (578) in the short sleep duration group, 38.29% (412) in the medium sleep duration group, and 7.99% (86) in the long sleep duration group. According to the crude model of the second-wave follow-up study, short sleep durations were significantly more strongly associated with possible sarcopenia than were medium and long sleep durations (OR: 1.35, 95% CI: 1.17-1.55, P = 0.000). The association between short sleep duration and possible sarcopenia was maintained even after adjustment for covariates such as age, gender, residence, education level, BMI, smoking status, alcohol consumption and comorbidities (OR: 1.18, 95% CI: 1.02-1.36, P = 0.029). In the subgroup analysis, short sleep duration was associated with low grip strength (OR: 1.20, 95% CI: 1.02-1.41, P = 0.031).
CONCLUSIONS: Sleep deprivation may be closely associated with the development of possible sarcopenia in middle-aged and elderly people, which provides new insights and ideas for sarcopenia intervention, and further studies are needed to reveal the underlying mechanisms involved.
METHODS: Two waves of data from the CHARLS database for 2011 and 2015 were used in this study. All possible sarcopenia participants met the Asia Working Group for Sarcopenia 2019 (AWGS 2019) diagnostic criteria. Sleep duration was assessed using a self-report questionnaire, and sleep duration was categorized as short (≤ 6 h), medium (6-8 h), or long (> 8 h) based on previous studies. Longitudinal associations between sleep duration and possible sarcopenia will be calculated by univariate and multifactorial logistic regression analyses and expressed as odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS: A total of 5654 individuals participated in the follow-up study, with a prevalence of possible sarcopenia of 53.72% (578) in the short sleep duration group, 38.29% (412) in the medium sleep duration group, and 7.99% (86) in the long sleep duration group. According to the crude model of the second-wave follow-up study, short sleep durations were significantly more strongly associated with possible sarcopenia than were medium and long sleep durations (OR: 1.35, 95% CI: 1.17-1.55, P = 0.000). The association between short sleep duration and possible sarcopenia was maintained even after adjustment for covariates such as age, gender, residence, education level, BMI, smoking status, alcohol consumption and comorbidities (OR: 1.18, 95% CI: 1.02-1.36, P = 0.029). In the subgroup analysis, short sleep duration was associated with low grip strength (OR: 1.20, 95% CI: 1.02-1.41, P = 0.031).
CONCLUSIONS: Sleep deprivation may be closely associated with the development of possible sarcopenia in middle-aged and elderly people, which provides new insights and ideas for sarcopenia intervention, and further studies are needed to reveal the underlying mechanisms involved.
摘要：
背景：肌肉减少症是老年人群残疾的常见原因，管理肌少症是建立内在能力和促进健康老龄化的重要一步。越来越多的证据表明，睡眠不足可能是肌少症发展的媒介。这项研究的目的是使用来自国家样本的数据探索睡眠持续时间与可能的肌少症之间的纵向关联。
方法：本研究使用了CHARLS数据库中2011年和2015年的两波数据。所有可能的肌肉减少症参与者均符合2019年亚洲肌肉减少症工作组（AWGS2019）的诊断标准。使用自我报告问卷评估睡眠时间，睡眠持续时间被归类为短（≤6小时），中等（6-8小时），或长（>8小时）基于以前的研究。睡眠持续时间和可能的肌肉减少症之间的纵向关联将通过单变量和多因素逻辑回归分析来计算，并表示为比值比（OR）和95％置信区间（CI）。
结果：共有5654人参加了随访研究，在短睡眠时间组中，可能的肌肉减少症患病率为53.72％（578），在中等睡眠持续时间组中，38.29%(412)，和7.99%(86)在长睡眠时间组。根据第二波随访研究的粗略模型，与中、长睡眠持续时间相比,短睡眠持续时间与可能的肌少症的相关性明显更强(OR:1.35,95%CI:1.17-1.55,P=0.000).短睡眠时间和可能的肌肉减少症之间的关联即使在调整了协变量，如年龄，性别,residence,教育水平,BMI,吸烟状况,饮酒和合并症（OR：1.18，95%CI：1.02-1.36，P=0.029）。在亚组分析中，睡眠时间短与握力低相关(OR:1.20,95%CI:1.02-1.41,P=0.031)。
结论：睡眠剥夺可能与中老年人可能的肌少症的发展密切相关，这为肌少症的干预提供了新的见解和思路，需要进一步的研究来揭示所涉及的潜在机制。
方法：本研究使用了CHARLS数据库中2011年和2015年的两波数据。所有可能的肌肉减少症参与者均符合2019年亚洲肌肉减少症工作组（AWGS2019）的诊断标准。使用自我报告问卷评估睡眠时间，睡眠持续时间被归类为短（≤6小时），中等（6-8小时），或长（>8小时）基于以前的研究。睡眠持续时间和可能的肌肉减少症之间的纵向关联将通过单变量和多因素逻辑回归分析来计算，并表示为比值比（OR）和95％置信区间（CI）。
结果：共有5654人参加了随访研究，在短睡眠时间组中，可能的肌肉减少症患病率为53.72％（578），在中等睡眠持续时间组中，38.29%(412)，和7.99%(86)在长睡眠时间组。根据第二波随访研究的粗略模型，与中、长睡眠持续时间相比,短睡眠持续时间与可能的肌少症的相关性明显更强(OR:1.35,95%CI:1.17-1.55,P=0.000).短睡眠时间和可能的肌肉减少症之间的关联即使在调整了协变量，如年龄，性别,residence,教育水平,BMI,吸烟状况,饮酒和合并症（OR：1.18，95%CI：1.02-1.36，P=0.029）。在亚组分析中，睡眠时间短与握力低相关(OR:1.20,95%CI:1.02-1.41,P=0.031)。
结论：睡眠剥夺可能与中老年人可能的肌少症的发展密切相关，这为肌少症的干预提供了新的见解和思路，需要进一步的研究来揭示所涉及的潜在机制。
