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Abstract：
To investigate alteration of outer nuclear layer (ONL) and choroidal vascularity index (CVI) in different status of central serous chorioretinopathy (CSC). A retrospective review of 65 CSC eyes with subretinal fluid (manifest CSC) and 40 control eyes was conducted in a single tertiary university hospital. Differences in best-corrected visual acuity (BCVA), ONL, and CVI were compared. CVI was assessed both in the entire choroid (CVI-EC) and around the 1500 μm leakage area (CVI-1500). Measurements were repeated after the subretinal fluid resorption (quiescent CSC), and compared. CSC eyes showed worse BCVA, thinner ONL and greater CVI than controls. Quiescent CSC showed a recovery of ONL compared to the manifest CSC, along with the BCVA improvement. The resolution of the CSC revealed a decrease across all three choroidal areas (total, stromal and luminal), with a more pronounced reduction in the stromal than in the luminal choroidal area, leading to an increase in the CVI. This phenomenon was shown in both CVI-EC and CVI-1500. Conclusively, ONL thickness can be used as a quantitative biomarker for photoreceptor function in CSC. Increased CVI may reflect a disease activity. The stromal choroidal area is particularly sensitive in illustrating leakage from the choroidal vasculature.
摘要：
探讨不同状态的中心性浆液性脉络膜视网膜病变(CSC)外核层(ONL)和脉络膜血管指数(CVI)的变化。在一家三级大学医院对65只患有视网膜下液（明显CSC）的CSC眼和40只对照眼进行了回顾性审查。最佳矫正视力（BCVA）的差异，ONL,和CVI进行了比较。在整个脉络膜（CVI-EC）和1500μm泄漏区域（CVI-1500）周围评估CVI。视网膜下液再吸收（静止CSC）后重复测量，和比较。CSC眼睛显示BCVA更差，比对照组更薄的ONL和更大的CVI。与清单CSC相比，静态CSC显示ONL恢复，随着BCVA的改进。CSC的分辨率显示所有三个脉络膜区域都有所下降(总计，基质和管腔)，与腔内脉络膜区域相比，基质的减少更明显，导致CVI增加。这种现象在CVI-EC和CVI-1500中均显示。最后，ONL厚度可用作CSC中光感受器功能的定量生物标志物。增加的CVI可能反映疾病活动。基质脉络膜区域在说明脉络膜脉管系统的渗漏时特别敏感。
