GolpHCAT (TMEM87A),高尔基体中独特的电压依赖性阳离子通道,有助于高尔基 pH 维持和海马依赖性记忆。
Mesh : Animals Humans Male Mice Astrocytes / metabolism Cognitive Dysfunction / metabolism physiopathology pathology Cryoelectron Microscopy Glycosylation Golgi Apparatus / metabolism HEK293 Cells Hippocampus / metabolism Hydrogen-Ion Concentration Ion Channels / metabolism genetics Membrane Proteins / metabolism genetics Memory / physiology Mice, Inbred C57BL Mice, Knockout Neurons / metabolism Spatial Memory / physiology
来 源:
DOI:10.1038/s41467-024-49297-8
PDF(Pubmed)