PDF(Pubmed)
Abstract：
We aimed to conduct a systematic review of the data in the literature on ovarian reserve and ovarian hormone following laparoscopic ovarian drilling (LOD). The PubMed, ScienceDirect, and ProQuest databases were comprehensively searched using a combination of keywords such as \"ovarian reserve\", \"laparoscopic ovarian drilling\", \"luteinizing hormone\", \"follicle-stimulating hormone\", \"inhibin\", \"LH/FSH ratio\", \"ovulation\", and \"testosterone\". All studies involving females of reproductive age who were officially diagnosed with polycystic ovarian syndrome (PCOS) and had undergone LOD with reported data concerning at least one of the following parameters were considered for inclusion: ovarian reserve, anti-Mullerian hormone (AMH), inhibin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH ratio, and testosterone. All the included studies were evaluated by the GRADE scale for bias and their findings were synthesized by four independent coauthors. A total of 38 studies involving 3118 female patients were included. Based on our findings, a significant number of participants experienced spontaneous ovulation along with a significant decrease in ovarian reserve, and a significant decrease in AMH, LH, and testosterone, with no significant changes in FSH and inhibin B. With the end goal of LOD being to improve fertility and pregnancy rates among females with PCOS, it is important to look at the first few steps that enable this. As expected, there was a significant improvement in ovulation while the ovarian reserve decreased. Along with the decrease in ovarian reserve, there was a significant normalization in AMH, LH, and testosterone levels. LOD may exert its main effects through the manipulation of the ovarian reserves.
摘要：
我们旨在对腹腔镜卵巢打孔（LOD）后卵巢储备和卵巢激素的文献数据进行系统评价。PubMed,ScienceDirect,和ProQuest数据库使用“卵巢储备”等关键词的组合进行了全面搜索，“腹腔镜卵巢打孔”，\"黄体生成素\",“促卵泡激素”，\"抑制素\",“LH/FSH比率”，“排卵”，和“睾丸激素”。所有涉及育龄女性的研究都被正式诊断为多囊卵巢综合征（PCOS），并接受了LOD，报告的数据至少包括以下参数之一：卵巢储备，抗苗勒管激素（AMH），抑制素,卵泡刺激素（FSH），黄体生成素(LH),LH/FSH比值,和睾丸激素。所有纳入的研究均通过GRADE量表进行偏倚评估，其结果由四个独立的合著者综合。共纳入38项研究，涉及3118名女性患者。根据我们的发现,大量参与者经历了自发排卵，同时卵巢储备显着下降，AMH显著下降，LH,和睾丸激素,FSH和抑制素B无显著变化，LOD的最终目标是提高PCOS女性的生育率和妊娠率，重要的是要看看实现这一点的前几个步骤。不出所料,排卵有显著改善,而卵巢储备功能下降.随着卵巢储备的减少，AMH有显著的正常化，LH,和睾丸激素水平。LOD可能通过操纵卵巢储备发挥其主要作用。
