PDF(Pubmed)
Abstract：
Folliculocystic and collagen hamartoma (FCCH) is a rare entity, typically documented in males with tuberous sclerosis complex. Here, we report a unique case of FCCH in a 19-year-old female with an unusual presentation in the external genitalia. The patient presented with a progressively enlarging mass over three years, causing difficulties in walking and sitting. Examination revealed a 10 x 15 cm tender, lobulated, skin-colored tumor with comedo-like openings originating from the right labium majus, with satellite lesions on both labia majora. She had no other symptoms or history suggestive of tuberous sclerosis. Histopathological examination showed dilated hair follicles with keratin, perifollicular fibrosis, and thick dermal collagen bands extending into subcutaneous tissue, confirming FCCH. This case underscores the importance of considering FCCH in the differential diagnosis of genital masses, even without classical clinical associations. Our findings contribute to the limited literature on FCCH and highlight the need for further exploration and awareness within the medical community.
摘要：
Follicocystic和胶原蛋白错构瘤（FCCH）是一种罕见的实体，通常记录在男性结节性硬化症。这里,我们报告了一例19岁女性FCCH的独特病例，外生殖器异常。患者在三年内表现出逐渐扩大的肿块，造成行走和坐着的困难。检查显示10x15厘米的嫩芽，分叶状,皮肤颜色的肿瘤，有来自右唇的粉刺样开口，两个大阴唇上都有卫星病变.她没有其他症状或病史提示结节性硬化症。组织病理学检查显示有角蛋白的毛囊扩张，卵泡周纤维化，和延伸到皮下组织的厚真皮胶原蛋白带，确认FCCH。该病例强调了在生殖器肿块的鉴别诊断中考虑FCCH的重要性，即使没有经典的临床关联。我们的发现有助于有关FCCH的有限文献，并强调了医学界进一步探索和认识的必要性。
