{Reference Type}: Case Reports {Title}: Giant Genital Mass: Unveiling a Unique Case of Folliculocystic and Collagen Hamartoma. {Author}: Mehta H;Gupta S;Bishnoi A;Chatterjee D;Vinay K; {Journal}: Cureus {Volume}: 16 {Issue}: 6 {Year}: 2024 Jun 暂无{DOI}: 10.7759/cureus.62036 {Abstract}: Folliculocystic and collagen hamartoma (FCCH) is a rare entity, typically documented in males with tuberous sclerosis complex. Here, we report a unique case of FCCH in a 19-year-old female with an unusual presentation in the external genitalia. The patient presented with a progressively enlarging mass over three years, causing difficulties in walking and sitting. Examination revealed a 10 x 15 cm tender, lobulated, skin-colored tumor with comedo-like openings originating from the right labium majus, with satellite lesions on both labia majora. She had no other symptoms or history suggestive of tuberous sclerosis. Histopathological examination showed dilated hair follicles with keratin, perifollicular fibrosis, and thick dermal collagen bands extending into subcutaneous tissue, confirming FCCH. This case underscores the importance of considering FCCH in the differential diagnosis of genital masses, even without classical clinical associations. Our findings contribute to the limited literature on FCCH and highlight the need for further exploration and awareness within the medical community.