■硬化外阴苔藓(VLS)是一种未被认识到的慢性炎症性皮肤病,具有显着的临床特征和恶性转化的潜力。迄今为止,没有研究将这种疾病在有色人种女性中的病程与其他种族群体进行比较。
■本研究的目的是提供一项范围审查,以检查VLS治疗研究中的种族人口统计数据,并特别评估是否纳入有色女性。
■使用首选报告项目进行系统审查和荟萃分析(PRISMA)指南,使用4个数据库进行了主要文献检索:OvidMedline(R),Scopus,科克伦,和WebofScience从所有年份到2022年12月。我们纳入了已发表的研究,该研究涉及诊断为VLS的成年女性,并包含使用局部皮质类固醇的治疗臂。单病例报告,文献综述,系统审查,荟萃分析,不包括英文报告。
■总的来说,评估了1340项非重复研究的资格标准。总的来说,包括65种出版物。只有6个包含种族人口数据。黑人妇女最多占样本人口的3.8%,拉丁裔妇女最多占5.7%。
■我们的评论集中在一种特定的干预措施上(即,使用局部皮质类固醇治疗VLS),这可能会限制我们的研究结果对其他干预措施的普遍性。由于审查的范围性质,没有进行偏见评估的风险。
在VLS成年女性中局部使用皮质类固醇的研究中,有色人种女性的代表性不足。招聘中的有意多样性将使收集的数据更加准确,并反映了更广泛的观点和生活经历。
UNASSIGNED: Vulvar lichen sclerosus (VLS) is an underrecognized chronic inflammatory skin condition with significant clinical features and potential for malignant transformation. To date, there are no studies comparing the course of this disease in women of color to other racial groups.
UNASSIGNED: The objective of this study was to provide a scoping review examining racial demographic data in VLS treatment studies and specifically assessing for the inclusion of women of color.
UNASSIGNED: Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a primary literature search was conducted using 4 databases: Ovid Medline(R), Scopus, Cochrane, and Web of Science from all years to December 2022. We included published studies with adult women diagnosed with VLS and containing a treatment arm using topical corticosteroids. Single case reports, literature reviews, systemic reviews, meta-analyses, and reports not available in English were excluded.
UNASSIGNED: Overall, 1340 nonduplicate studies were assessed for eligibility criteria. In total, 65 publications were included. Only 6 included racial demographic data. Black women made up at most 3.8% of the sample population and Latinx women made up at most 5.7%.
UNASSIGNED: Our review focused on a specific intervention (ie, the use of topical corticosteroids for the treatment of VLS), which may restrict the generalizability of our findings to other interventions. No risk of bias assessment was done due to the scoping nature of the review.
UNASSIGNED: Women of color are underrepresented in studies of topical corticosteroid use in adult women with VLS. Intentional diversity in recruitment will enable the collection of data that is both more accurate and reflective of a broader spectrum of perspectives and life experiences.