PDF(Pubmed)
Abstract：
UNASSIGNED: Ashwagandha is a well-known Ayurvedic herb used for youthful vigor and wellbeing. This study investigated the effects of 600 mg standardized root extract (>5% withanolides) of Ashwagandha ( Withania somnifera) on muscle size, strength and cardiorespiratory endurance following resistance training.
UNASSIGNED: In this eight-week, parallel-group, multicenter, randomized, double-blind, placebo-controlled clinical study, 80 healthy male and female participants aged 18-45 years, who engaged in regular physical activity were randomly allocated in a 1:1 ratio to receive Ashwagandha (AG, n=40) 300 mg capsules twice daily for eight weeks, or identical placebo (PB, n=40). Seven (3 AG, 4 PB) participants were excluded due to poor compliance. All participants conducted eight-week resistance training. Study outcomes included muscle strength (1RM bench press and leg extension), muscle size (circumference of arm, chest and upper thigh) and cardio-respiratory endurance (VO 2max) assessed at baseline and at eight weeks. Analysis of covariance (ANCOVA) was used to estimate adjusted differences based on sex, BMI and chest circumference at baseline.
UNASSIGNED: AG caused greater improvement in bench press (males: p = 0.0084; females: p = 0.0005), leg press (males: p = 0.0049; females: p = 0.018) and endurance (males: p <0.0001; females: p <0.0001) as compared to PB. Also, greater improvements in muscle girth for arm, chest and thigh were seen in both male and female participants with AG. No adverse events were reported in the study.
UNASSIGNED: Eight weeks of AG root extract supplementation along with resistance training is effective in improving muscle strength, growth and endurance in both male and female participants. AG root extract could be a safer, effective and low-cost alternative for athletes to improve muscle endurance.
UNASSIGNED: In this eight-week, parallel-group, multicenter, randomized, double-blind, placebo-controlled clinical study, 80 healthy male and female participants aged 18-45 years, who engaged in regular physical activity were randomly allocated in a 1:1 ratio to receive Ashwagandha (AG, n=40) 300 mg capsules twice daily for eight weeks, or identical placebo (PB, n=40). Seven (3 AG, 4 PB) participants were excluded due to poor compliance. All participants conducted eight-week resistance training. Study outcomes included muscle strength (1RM bench press and leg extension), muscle size (circumference of arm, chest and upper thigh) and cardio-respiratory endurance (VO 2max) assessed at baseline and at eight weeks. Analysis of covariance (ANCOVA) was used to estimate adjusted differences based on sex, BMI and chest circumference at baseline.
UNASSIGNED: AG caused greater improvement in bench press (males: p = 0.0084; females: p = 0.0005), leg press (males: p = 0.0049; females: p = 0.018) and endurance (males: p <0.0001; females: p <0.0001) as compared to PB. Also, greater improvements in muscle girth for arm, chest and thigh were seen in both male and female participants with AG. No adverse events were reported in the study.
UNASSIGNED: Eight weeks of AG root extract supplementation along with resistance training is effective in improving muscle strength, growth and endurance in both male and female participants. AG root extract could be a safer, effective and low-cost alternative for athletes to improve muscle endurance.
摘要：
■Ashwagandha是一种著名的阿育吠陀草药，用于年轻的活力和幸福。这项研究调查了Ashwagandha（Withaniasomnifera）的600毫克标准化根提取物（>5％withanolides）对肌肉大小的影响，抗阻训练后的力量和心肺耐力。
■在这八周中，平行组，多中心，随机化，双盲,安慰剂对照临床研究，80名年龄在18-45岁的健康男性和女性参与者，从事定期体育锻炼的人以1：1的比例随机分配接受Ashwagandha(AG，n=40)300毫克胶囊，每日两次，持续八周，或相同的安慰剂(PB，n=40)。七（3AG，4PB)的参与者由于依从性差被排除在外。所有参与者都进行了为期8周的阻力训练。研究结果包括肌肉力量（1RM卧推和腿部伸展），肌肉大小（手臂的周长，在基线和八周时评估胸部和大腿上部）和心肺耐力（VO2max）。协方差分析(ANCOVA)用于估计基于性别的调整后差异，基线时的BMI和胸围。
■AG在卧推方面引起了更大的改善（男性：p=0.0084；女性：p=0.0005），与PB相比，腿部压力（男性：p=0.0049；女性：p=0.018）和耐力（男性：p<0.0001；女性：p<0.0001）。此外，手臂的肌肉周长有了更大的改善，在AG患者的男性和女性参与者中均可见胸部和大腿。研究中未报告不良事件。
■八周的AG根提取物补充以及阻力训练可有效提高肌肉力量，男性和女性参与者的生长和耐力。AG根提取物可能更安全，有效和低成本的替代运动员，以提高肌肉耐力。
■在这八周中，平行组，多中心，随机化，双盲,安慰剂对照临床研究，80名年龄在18-45岁的健康男性和女性参与者，从事定期体育锻炼的人以1：1的比例随机分配接受Ashwagandha(AG，n=40)300毫克胶囊，每日两次，持续八周，或相同的安慰剂(PB，n=40)。七（3AG，4PB)的参与者由于依从性差被排除在外。所有参与者都进行了为期8周的阻力训练。研究结果包括肌肉力量（1RM卧推和腿部伸展），肌肉大小（手臂的周长，在基线和八周时评估胸部和大腿上部）和心肺耐力（VO2max）。协方差分析(ANCOVA)用于估计基于性别的调整后差异，基线时的BMI和胸围。
■AG在卧推方面引起了更大的改善（男性：p=0.0084；女性：p=0.0005），与PB相比，腿部压力（男性：p=0.0049；女性：p=0.018）和耐力（男性：p<0.0001；女性：p<0.0001）。此外，手臂的肌肉周长有了更大的改善，在AG患者的男性和女性参与者中均可见胸部和大腿。研究中未报告不良事件。
■八周的AG根提取物补充以及阻力训练可有效提高肌肉力量，男性和女性参与者的生长和耐力。AG根提取物可能更安全，有效和低成本的替代运动员，以提高肌肉耐力。
