METHODS: Medline, Scopus, and Google Scholar databases were systematically searched up to November 2023. The Cochrane Collaboration tool was used to assess the risk of bias and the quality of the studies. The random-effects model, weighted mean difference (WMD), and 95% confidence interval (CI) were used to estimate the overall effect. Between-study heterogeneity was assessed using the chi-squared and I2 tests.
RESULTS: Seventeen studies were included in the present systematic review and 16 studies were included in the meta-analysis. The pooled results from 16 studies (21 trials) with 1170 participants examining the impact of exercise on IGF-1 concentration showed a significant increase in IGF-1, and the pooled results among six studies (trials) showed a significant decrease in IGFBP-3 concentration (730 participants). In addition, resistance training and aerobic training had a significant effect on increasing IGF-1 concentration post-exercise compared with placebo.
CONCLUSIONS: Based on this meta-analysis, Women who have completed menopause and followed an exercise routine showed changes in IGF-1 and IGFBP-3 levels that can indirectly be associated with risk of chronic age-related conditions.
方法:Medline,Scopus,截至2023年11月,系统搜索了GoogleScholar数据库。Cochrane协作工具用于评估偏倚风险和研究质量。随机效应模型,加权平均差(WMD),和95%置信区间(CI)用于估计总体效果。使用卡方检验和I2检验评估研究之间的异质性。
结果:本系统综述包括17项研究,荟萃分析包括16项研究。来自16项研究(21项试验)的汇总结果,有1170名参与者检查了运动对IGF-1浓度的影响,结果显示IGF-1显着增加,而六项研究(试验)的汇总结果显示IGFBP-3浓度显着降低(730名参与者)。此外,与安慰剂相比,抗阻训练和有氧训练对提高运动后IGF-1浓度有显著影响.
结论:基于此荟萃分析,完成绝经并遵循常规运动的女性显示IGF-1和IGFBP-3水平的变化,这可能间接与慢性年龄相关疾病的风险有关。