PDF(Pubmed)
Abstract：
Adeno-associated viruses (AAVs) are promising gene therapy vectors, but challenges arise when treating patients with preexisting neutralizing antibodies. Worldwide seroprevalence studies provide snapshots of existing immunity in diverse populations. Owing to the uniqueness of the Basque socio-geographical landscape, we investigated the seroprevalence of eight AAV serotypes in residents of the Basque Country. We found the highest seroprevalence of AAV3, and the lowest seroprevalence of AAV9. Additionally, less than 50% of the Basque population has neutralizing antibodies against AAV4, AAV6, and AAV9. Our findings provide insight into AAV infections in the Basque region, public health, and the development of AAV-based therapeutics.
摘要：
腺相关病毒（AAV）是有前途的基因治疗载体，但是当用预先存在的中和抗体治疗患者时，就会出现挑战。全球血清阳性率研究提供了不同人群中现有免疫的快照。由于巴斯克地区社会地理景观的独特性,我们调查了巴斯克地区居民中8种AAV血清型的血清阳性率。我们发现AAV3的血清阳性率最高，AAV9的血清阳性率最低。此外,不到50%的巴斯克人群具有抗AAV4,AAV6和AAV9的中和抗体.我们的发现为巴斯克地区的AAV感染提供了见解，公共卫生,以及基于AAV的疗法的发展。
