在阿尔茨海默病大鼠模型中, 适度的有氧训练通过下丘脑 IGF1 信号增强胰岛素治疗的有效性。
关键词: Alzheimer’s disease Insulin Metabolism Spatial learning and memory Treadmill exercise
Mesh : Animals Alzheimer Disease / metabolism drug therapy therapy Insulin-Like Growth Factor I / metabolism Physical Conditioning, Animal Male Insulin / metabolism Disease Models, Animal Rats Hypothalamus / metabolism Rats, Wistar Signal Transduction / drug effects Glucose Transporter Type 4 / metabolism genetics Amyloid beta-Peptides / metabolism Brain-Derived Neurotrophic Factor / metabolism genetics Hippocampus / metabolism drug effects Administration, Intranasal Peptide Fragments Spatial Memory / drug effects Spatial Learning / drug effects
来 源:
DOI:10.1038/s41598-024-66637-2
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