Abstract：
Libman-Sacks endocarditis is an important cause of embolic stroke in systemic lupus erythematosus, although the detailed pathogenesis of stroke remains unclear. We herein report two cases of stroke with Libman-Sacks endocarditis in which the emboli were retrieved by mechanical thrombectomy. The embolus consisted of eosinophilic homogeneous acellular structures, whereas fibrin-platelet thrombi were hardly observed in the embolus. Immunohistochemistry showed immunoglobulin deposits in the embolus, suggesting that immunological mechanisms were involved in the growth of the embolus. A pathological analysis of the embolus retrieved by mechanical thrombectomy provided useful information on the etiology, leading to optimal treatment.
摘要：
Libman-Sacks心内膜炎是系统性红斑狼疮栓塞性卒中的重要原因,虽然中风的详细发病机制尚不清楚。我们在此报告了两例Libman-Sacks心内膜炎的中风病例，其中通过机械血栓切除术取回了栓子。栓子由嗜酸性同质脱细胞结构组成，而在栓子中几乎观察不到纤维蛋白-血小板血栓。免疫组织化学显示栓子中有免疫球蛋白沉积,提示免疫机制参与了栓子的生长。通过机械血栓切除术检索到的栓子的病理分析提供了有关病因的有用信息，导致最佳治疗。
