{Reference Type}: Journal Article
{Title}: Pathological Findings of Embolus Retrieved by Mechanical Thrombectomy in Cerebral Embolism with Libman-Sacks Endocarditis: A Report of Two Cases.
{Author}: Kodera H;Sakamoto Y;Aoki J;Kimura R;Matsumoto N;Nishiyama Y;Kunugi S;Kimura K;
{Journal}: Intern Med
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 11
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.3212-23
{Abstract}: Libman-Sacks endocarditis is an important cause of embolic stroke in systemic lupus erythematosus, although the detailed pathogenesis of stroke remains unclear. We herein report two cases of stroke with Libman-Sacks endocarditis in which the emboli were retrieved by mechanical thrombectomy. The embolus consisted of eosinophilic homogeneous acellular structures, whereas fibrin-platelet thrombi were hardly observed in the embolus. Immunohistochemistry showed immunoglobulin deposits in the embolus, suggesting that immunological mechanisms were involved in the growth of the embolus. A pathological analysis of the embolus retrieved by mechanical thrombectomy provided useful information on the etiology, leading to optimal treatment.