Abstract：
BACKGROUND: Some epidemiological data suggest that there may be an inverse relationship between cholesterol levels and the risk of thyroid cancer in the overall population. The present study was aimed to evaluate the lipid profile specifically in subjects with Bethesda category IV thyroid nodules, and compare whether there were any differences between those with benign and malignant nodules.
METHODS: Single-centre, retrospective study on 204 subjects treated by partial or total thyroidectomy for excision of a Bethesda category IV thyroid nodule, who had undergone a blood lipid profile test in the 12 months prior to surgery. In addition to lipid measures, other demographic, clinical, biochemical and ultrasound data were collected.
RESULTS: Seventy-five subjects (36.8%) were diagnosed with thyroid carcinoma in the definitive histopathological examination. Patients with thyroid cancer had lower levels of total cholesterol, LDL-cholesterol and non-HDL-cholesterol than subjects with benign thyroid diseases. There were no differences in HDL-cholesterol, triglycerides or total cholesterol/HDL-cholesterol ratio. There were no differences either between groups in other clinical, biochemical and ultrasound variables, including the use of lipid-lowering drugs. In multivariate analysis, only LDL-cholesterol was independently associated with malignancy. Subjects with follicular carcinoma showed the lowest cholesterol levels, while those with papillary carcinoma had intermediate values between the group with follicular carcinoma and the group with benign thyroid diseases.
CONCLUSIONS: In subjects with cytologically indeterminate Bethesda category IV thyroid nodules, levels of total cholesterol, non-HDL-cholesterol and, particularly, LDL-cholesterol are lower among those with malignant nodules.
METHODS: Single-centre, retrospective study on 204 subjects treated by partial or total thyroidectomy for excision of a Bethesda category IV thyroid nodule, who had undergone a blood lipid profile test in the 12 months prior to surgery. In addition to lipid measures, other demographic, clinical, biochemical and ultrasound data were collected.
RESULTS: Seventy-five subjects (36.8%) were diagnosed with thyroid carcinoma in the definitive histopathological examination. Patients with thyroid cancer had lower levels of total cholesterol, LDL-cholesterol and non-HDL-cholesterol than subjects with benign thyroid diseases. There were no differences in HDL-cholesterol, triglycerides or total cholesterol/HDL-cholesterol ratio. There were no differences either between groups in other clinical, biochemical and ultrasound variables, including the use of lipid-lowering drugs. In multivariate analysis, only LDL-cholesterol was independently associated with malignancy. Subjects with follicular carcinoma showed the lowest cholesterol levels, while those with papillary carcinoma had intermediate values between the group with follicular carcinoma and the group with benign thyroid diseases.
CONCLUSIONS: In subjects with cytologically indeterminate Bethesda category IV thyroid nodules, levels of total cholesterol, non-HDL-cholesterol and, particularly, LDL-cholesterol are lower among those with malignant nodules.
摘要：
背景：一些流行病学数据表明，在总体人群中，胆固醇水平与甲状腺癌风险之间可能存在反比关系。本研究旨在评估BethesdaIV类甲状腺结节患者的血脂分布。并比较良性和恶性结节之间是否有任何差异。
方法：单中心，对204例接受部分或全甲状腺切除术切除BethesdaIV类甲状腺结节的受试者进行回顾性研究，在手术前12个月接受过血脂测试的人。除了血脂测量，其他人口，临床,收集生化和超声数据。
结果：75名受试者（36.8%）在明确的组织病理学检查中被诊断为甲状腺癌。甲状腺癌患者的总胆固醇水平较低，LDL-胆固醇和非HDL-胆固醇比良性甲状腺疾病的受试者。HDL-胆固醇没有差异，甘油三酯或总胆固醇/HDL-胆固醇比率。在其他临床上，两组之间也没有差异，生化和超声变量，包括使用降脂药物。在多变量分析中，只有LDL-胆固醇与恶性肿瘤独立相关.滤泡性癌患者的胆固醇水平最低，而乳头状癌患者的价值介于滤泡状癌组和良性甲状腺疾病组之间。
结论：在细胞学不确定的BethesdaIV类甲状腺结节的受试者中，总胆固醇水平，非HDL-胆固醇和，特别是,在患有恶性结节的人群中，LDL-胆固醇较低。
方法：单中心，对204例接受部分或全甲状腺切除术切除BethesdaIV类甲状腺结节的受试者进行回顾性研究，在手术前12个月接受过血脂测试的人。除了血脂测量，其他人口，临床,收集生化和超声数据。
结果：75名受试者（36.8%）在明确的组织病理学检查中被诊断为甲状腺癌。甲状腺癌患者的总胆固醇水平较低，LDL-胆固醇和非HDL-胆固醇比良性甲状腺疾病的受试者。HDL-胆固醇没有差异，甘油三酯或总胆固醇/HDL-胆固醇比率。在其他临床上，两组之间也没有差异，生化和超声变量，包括使用降脂药物。在多变量分析中，只有LDL-胆固醇与恶性肿瘤独立相关.滤泡性癌患者的胆固醇水平最低，而乳头状癌患者的价值介于滤泡状癌组和良性甲状腺疾病组之间。
结论：在细胞学不确定的BethesdaIV类甲状腺结节的受试者中，总胆固醇水平，非HDL-胆固醇和，特别是,在患有恶性结节的人群中，LDL-胆固醇较低。
