METHODS: This study included patients with AC who underwent pancreaticoduodenectomy (PD) with curative intention at Ogaki Municipal Hospital from April 2008 to March 2023.
RESULTS: Fifty-five patients underwent LPD (n = 26) or OPD (n = 29). There were no significant differences in the demographics between the two groups. The LPD group had a significantly longer operative time (268 vs. 225 min), less blood loss (125 vs. 450 mL), and shorter postoperative hospital stay (18 vs. 23 days) than the OPD group. There was no significant difference in the morbidity ratio. Fewer lymph nodes were harvested in the LPD group than OPD group (9.5 vs. 16.0), but there were no significant differences in lymph node metastasis or pathological stages. There were no significant differences in overall survival (OS) or recurrence-free survival (RFS). The 3- and 5-year OS rates in the LPD group and the OPD group were 63.0% and 54%, 64.8%, and 61.2%, respectively. The 3- and 5-year RFS rates were 57.4% and 57.4%, 58.1%, and 54.4%, respectively.
CONCLUSIONS: LPD for AC had short- and long-term outcomes comparable with those of OPD. LPD could be considered the standard treatments for AC because of less blood loss and a shorter hospital stay.
方法:本研究纳入了2008年4月至2023年3月在大崎市立医院接受胰十二指肠切除术(PD)治疗的AC患者。
结果:55例患者接受了LPD(n=26)或OPD(n=29)。两组人口统计学差异无统计学意义。LPD组的手术时间明显更长(268vs.225分钟),减少失血(125vs.450mL),术后住院时间较短(18vs.23天)比OPD组。发病率没有显着差异。LPD组比OPD组收集的淋巴结少(9.5vs.16.0),但在淋巴结转移或病理分期上无明显差异。总生存期(OS)或无复发生存期(RFS)无显著差异。LPD组和OPD组的3年和5年OS率分别为63.0%和54%,64.8%,和61.2%,分别。3年和5年RFS率分别为57.4%和57.4%,58.1%,和54.4%,分别。
结论:LPD治疗AC的短期和长期结果与OPD相当。LPD可以被认为是AC的标准治疗,因为其失血更少并且住院时间更短。