RESULTS: This study examines the direct physiological impact of polar lipid supplementation, in the form of buttermilk powder, on primary cortical neuron growth and maturation. The changes are measured with postsynaptic current response recordings, immunohistochemical examination of functional synapse localization and numbers, and the biochemical quantification of receptors responsible for neuronal synaptic neurotransmission. Chronic exposure to polar lipids increases primary mouse cortical neuron basal excitatory synapse response strength attributed to enhanced dendritic complexity and an altered expression of the excitatory α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit 2 (GluR2).
CONCLUSIONS: The present finding suggests that dietary polar lipids improve human cognition through an enhancement of neuronal maturation and/or function.
结果:本研究检查了极性脂质补充的直接生理影响,以酪乳粉的形式,对原代皮层神经元生长和成熟的影响。这些变化是用突触后电流反应记录来测量的,功能突触定位和数量的免疫组织化学检查,以及负责神经元突触神经传递的受体的生化定量。长期暴露于极性脂质可增加小鼠皮层神经元基础兴奋性突触反应强度,这归因于树突复杂性增强和兴奋性α-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA)受体亚基2(GluR2)的表达改变。
结论:本发现提示膳食极性脂质通过增强神经元成熟和/或功能来改善人类认知。