Abstract:
Cerebrospinal fluid-contacting neurons (CSF-cNs) represent a distinct group of interneurons characterized by their prominent apical globular protrusions penetrating the spinal cord\'s central canal and their basal axons extending towards adjacent cells. Identified nearly a century back, the specific roles and attributes of CSF-cNs have just started to emerge due to the historical lack of definitive markers. Recent findings have confirmed that CSF-cNs expressing PKD2L1 possess attributes of neural stem cells, suggesting a critical function in the regeneration processes following spinal cord injuries. This review aims to elucidate the molecular markers of CSF-cNs as potential neural stem cells during spinal cord development and assess their roles post-spinal cord injury, with an emphasis on their potential therapeutic implications for spinal cord repair.
摘要:
脑脊液接触神经元(CSF-cNs)代表一组独特的中间神经元,其特征是其突出的顶端球形突起穿透脊髓的中央管,其基底轴突向相邻细胞延伸。近一个世纪前确定,由于历史上缺乏明确的标记,CSF-cNs的特定作用和属性才刚刚开始出现.最近的发现已经证实,表达PKD2L1的CSF-cNs具有神经干细胞的属性,提示脊髓损伤后再生过程中的关键功能。本文旨在阐明CSF-cNs作为脊髓发育过程中潜在神经干细胞的分子标志物,并评估其在脊髓损伤后的作用。强调它们对脊髓修复的潜在治疗意义。