Roles of cerebrospinal fluid-contacting neurons as potential neural stem cells in the repair and regeneration of spinal cord injuries.

脑脊液接触神经元作为潜在的神经干细胞在脊髓损伤修复和再生中的作用。

• 影响指数: 6.081
• 发表时间: 2024
• 来源期刊: Front Cell Dev Biol
• DOI: 10.3389/fcell.2024.1426395
• PMID: 38983786
• 文章类型: Journal Article
• 作者列表: Xiong Y,Pi W,Zhao W,Shi W,Yan W,Yang H,Zhou Y,Li Q,Yang L

关键词: CSF-cNs; PKD2L1; neural regeneration; neural stem cells; repair; spinal cord injury

Abstract

Cerebrospinal fluid-contacting neurons (CSF-cNs) represent a distinct group of interneurons characterized by their prominent apical globular protrusions penetrating the spinal cord\'s central canal and their basal axons extending towards adjacent cells. Identified nearly a century back, the specific roles and attributes of CSF-cNs have just started to emerge due to the historical lack of definitive markers. Recent findings have confirmed that CSF-cNs expressing PKD2L1 possess attributes of neural stem cells, suggesting a critical function in the regeneration processes following spinal cord injuries. This review aims to elucidate the molecular markers of CSF-cNs as potential neural stem cells during spinal cord development and assess their roles post-spinal cord injury, with an emphasis on their potential therapeutic implications for spinal cord repair.

摘要

脑脊液接触神经元（CSF-cNs）代表一组独特的中间神经元，其特征是其突出的顶端球形突起穿透脊髓的中央管，其基底轴突向相邻细胞延伸。近一个世纪前确定，由于历史上缺乏明确的标记,CSF-cNs的特定作用和属性才刚刚开始出现.最近的发现已经证实，表达PKD2L1的CSF-cNs具有神经干细胞的属性，提示脊髓损伤后再生过程中的关键功能。本文旨在阐明CSF-cNs作为脊髓发育过程中潜在神经干细胞的分子标志物，并评估其在脊髓损伤后的作用。强调它们对脊髓修复的潜在治疗意义。