{Reference Type}: Journal Article
{Title}: Roles of cerebrospinal fluid-contacting neurons as potential neural stem cells in the repair and regeneration of spinal cord injuries.
{Author}: Xiong Y;Pi W;Zhao W;Shi W;Yan W;Yang H;Zhou Y;Li Q;Yang L;
{Journal}: Front Cell Dev Biol
{Volume}: 12
{Issue}: 0
{Year}: 2024
{Factor}: 6.081
{DOI}: 10.3389/fcell.2024.1426395
{Abstract}: Cerebrospinal fluid-contacting neurons (CSF-cNs) represent a distinct group of interneurons characterized by their prominent apical globular protrusions penetrating the spinal cord's central canal and their basal axons extending towards adjacent cells. Identified nearly a century back, the specific roles and attributes of CSF-cNs have just started to emerge due to the historical lack of definitive markers. Recent findings have confirmed that CSF-cNs expressing PKD2L1 possess attributes of neural stem cells, suggesting a critical function in the regeneration processes following spinal cord injuries. This review aims to elucidate the molecular markers of CSF-cNs as potential neural stem cells during spinal cord development and assess their roles post-spinal cord injury, with an emphasis on their potential therapeutic implications for spinal cord repair.