OBJECTIVE: To determine whether smoking is linked to the recurrence and progression of bladder cancer.
METHODS: As of July 20, 2022, relevant English-language research was identified by searching PubMed, the Web of Science, and the Cochrane Library. We pooled the available data from the included studies using a random effects model. Subgroup analysis and sensitivity analysis were also conducted.
RESULTS: A total of 12 studies were included in this meta-analysis. The combined analysis revealed that tobacco exposure was associated with a significantly greater recurrence rate than nonsmoking status [odd ratios (OR) = 1.76, 95%CI: 1.84-2.93], and the progression of bladder cancer was significantly greater in smokers than in nonsmokers (OR = 1.21, 95%CI: 1.02-1.44). Stratified analysis further revealed that current smokers were more likely to experience relapse than never-smokers were (OR = 1.85, 95%CI: 1.11-3.07). Former smokers also had a greater risk of relapse than did never-smokers (OR = 1.73, 95%CI: 1.09-2.73). Subgroup analysis indicated that non-Caucasians may be more susceptible to bladder cancer recurrence than Caucasians are (OR = 2.13, 95%CI: 1.74-2.61).
CONCLUSIONS: This meta-analysis revealed that tobacco exposure may be a significant risk factor for both the recurrence and progression of bladder cancer.
目的:确定吸烟是否与膀胱癌的复发和进展有关。
方法:截至2022年7月20日,通过搜索PubMed,确定了相关的英语研究,WebofScience,还有Cochrane图书馆.我们使用随机效应模型汇总了纳入研究的可用数据。同时进行亚组分析和敏感性分析。
结果:本荟萃分析共纳入12项研究。综合分析显示,与不吸烟状态相比,烟草暴露与复发率显着相关[奇数比(OR)=1.76,95CI:1.84-2.93],吸烟者的膀胱癌进展明显大于非吸烟者(OR=1.21,95CI:1.02-1.44).分层分析进一步显示,当前吸烟者比从未吸烟者更容易复发(OR=1.85,95CI:1.11-3.07)。与从未吸烟者相比,前吸烟者的复发风险也更大(OR=1.73,95CI:1.09-2.73)。亚组分析表明,非白种人可能比白种人更容易患膀胱癌复发(OR=2.13,95CI:1.74-2.61)。
结论:这项荟萃分析显示,烟草暴露可能是膀胱癌复发和进展的重要危险因素。