PDF(Pubmed)
Abstract：
BACKGROUND: However, the connection between smoking and the prognosis of patients with bladder cancer remains unclear.
OBJECTIVE: To determine whether smoking is linked to the recurrence and progression of bladder cancer.
METHODS: As of July 20, 2022, relevant English-language research was identified by searching PubMed, the Web of Science, and the Cochrane Library. We pooled the available data from the included studies using a random effects model. Subgroup analysis and sensitivity analysis were also conducted.
RESULTS: A total of 12 studies were included in this meta-analysis. The combined analysis revealed that tobacco exposure was associated with a significantly greater recurrence rate than nonsmoking status [odd ratios (OR) = 1.76, 95%CI: 1.84-2.93], and the progression of bladder cancer was significantly greater in smokers than in nonsmokers (OR = 1.21, 95%CI: 1.02-1.44). Stratified analysis further revealed that current smokers were more likely to experience relapse than never-smokers were (OR = 1.85, 95%CI: 1.11-3.07). Former smokers also had a greater risk of relapse than did never-smokers (OR = 1.73, 95%CI: 1.09-2.73). Subgroup analysis indicated that non-Caucasians may be more susceptible to bladder cancer recurrence than Caucasians are (OR = 2.13, 95%CI: 1.74-2.61).
CONCLUSIONS: This meta-analysis revealed that tobacco exposure may be a significant risk factor for both the recurrence and progression of bladder cancer.
OBJECTIVE: To determine whether smoking is linked to the recurrence and progression of bladder cancer.
METHODS: As of July 20, 2022, relevant English-language research was identified by searching PubMed, the Web of Science, and the Cochrane Library. We pooled the available data from the included studies using a random effects model. Subgroup analysis and sensitivity analysis were also conducted.
RESULTS: A total of 12 studies were included in this meta-analysis. The combined analysis revealed that tobacco exposure was associated with a significantly greater recurrence rate than nonsmoking status [odd ratios (OR) = 1.76, 95%CI: 1.84-2.93], and the progression of bladder cancer was significantly greater in smokers than in nonsmokers (OR = 1.21, 95%CI: 1.02-1.44). Stratified analysis further revealed that current smokers were more likely to experience relapse than never-smokers were (OR = 1.85, 95%CI: 1.11-3.07). Former smokers also had a greater risk of relapse than did never-smokers (OR = 1.73, 95%CI: 1.09-2.73). Subgroup analysis indicated that non-Caucasians may be more susceptible to bladder cancer recurrence than Caucasians are (OR = 2.13, 95%CI: 1.74-2.61).
CONCLUSIONS: This meta-analysis revealed that tobacco exposure may be a significant risk factor for both the recurrence and progression of bladder cancer.
摘要：
背景：然而，吸烟与膀胱癌患者预后之间的关系尚不清楚.
目的：确定吸烟是否与膀胱癌的复发和进展有关。
方法：截至2022年7月20日，通过搜索PubMed，确定了相关的英语研究，WebofScience,还有Cochrane图书馆.我们使用随机效应模型汇总了纳入研究的可用数据。同时进行亚组分析和敏感性分析。
结果：本荟萃分析共纳入12项研究。综合分析显示，与不吸烟状态相比，烟草暴露与复发率显着相关[奇数比（OR）=1.76，95CI：1.84-2.93]，吸烟者的膀胱癌进展明显大于非吸烟者(OR=1.21,95CI:1.02-1.44).分层分析进一步显示，当前吸烟者比从未吸烟者更容易复发（OR=1.85，95CI：1.11-3.07）。与从未吸烟者相比，前吸烟者的复发风险也更大（OR=1.73，95CI：1.09-2.73）。亚组分析表明，非白种人可能比白种人更容易患膀胱癌复发（OR=2.13，95CI：1.74-2.61）。
结论：这项荟萃分析显示，烟草暴露可能是膀胱癌复发和进展的重要危险因素。
目的：确定吸烟是否与膀胱癌的复发和进展有关。
方法：截至2022年7月20日，通过搜索PubMed，确定了相关的英语研究，WebofScience,还有Cochrane图书馆.我们使用随机效应模型汇总了纳入研究的可用数据。同时进行亚组分析和敏感性分析。
结果：本荟萃分析共纳入12项研究。综合分析显示，与不吸烟状态相比，烟草暴露与复发率显着相关[奇数比（OR）=1.76，95CI：1.84-2.93]，吸烟者的膀胱癌进展明显大于非吸烟者(OR=1.21,95CI:1.02-1.44).分层分析进一步显示，当前吸烟者比从未吸烟者更容易复发（OR=1.85，95CI：1.11-3.07）。与从未吸烟者相比，前吸烟者的复发风险也更大（OR=1.73，95CI：1.09-2.73）。亚组分析表明，非白种人可能比白种人更容易患膀胱癌复发（OR=2.13，95CI：1.74-2.61）。
结论：这项荟萃分析显示，烟草暴露可能是膀胱癌复发和进展的重要危险因素。
