%0 Journal Article
%T Association between tobacco exposure and bladder cancer recurrence: A systematic review and meta-analysis.
%A Xiang L
%A Xie QQ
%A Xu SS
%A Ruan WJ
%A Xu DH
%A Gan YY
%A Zuo J
%A Xu WJ
%A Li ZP
%J World J Methodol
%V 14
%N 2
%D 2024 Jun 20
%M 38983655
暂无%R 10.5662/wjm.v14.i2.91889
%X <B>BACKGROUND: </B>However, the connection between smoking and the prognosis of patients with bladder cancer remains unclear.<BR><B>OBJECTIVE: </B>To determine whether smoking is linked to the recurrence and progression of bladder cancer.<BR><B>METHODS: </B>As of July 20, 2022, relevant English-language research was identified by searching PubMed, the Web of Science, and the Cochrane Library. We pooled the available data from the included studies using a random effects model. Subgroup analysis and sensitivity analysis were also conducted.<BR><B>RESULTS: </B>A total of 12 studies were included in this meta-analysis. The combined analysis revealed that tobacco exposure was associated with a significantly greater recurrence rate than nonsmoking status [odd ratios (OR) = 1.76, 95%CI: 1.84-2.93], and the progression of bladder cancer was significantly greater in smokers than in nonsmokers (OR = 1.21, 95%CI: 1.02-1.44). Stratified analysis further revealed that current smokers were more likely to experience relapse than never-smokers were (OR = 1.85, 95%CI: 1.11-3.07). Former smokers also had a greater risk of relapse than did never-smokers (OR = 1.73, 95%CI: 1.09-2.73). Subgroup analysis indicated that non-Caucasians may be more susceptible to bladder cancer recurrence than Caucasians are (OR = 2.13, 95%CI: 1.74-2.61).<BR><B>CONCLUSIONS: </B>This meta-analysis revealed that tobacco exposure may be a significant risk factor for both the recurrence and progression of bladder cancer.