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Abstract：
BACKGROUND: Lumbar disc herniation (LDH) commonly occurs during spinal surgery; LDH is on the increase in younger patients and is classified as \"paralysis\" and \"back pain.\" Sanhanchushi Tongbi (SPST) is a customized prescription. It disperses cold, relieves pain, removes cold from the meridians and viscera, and treats neuropathic pain. However, few studies have investigated its mechanism of pain relief.
OBJECTIVE: To observe the clinical therapeutic effects on LDH treated with self-prescribed SPST.
METHODS: A total of 211 patients with LDH syndrome were divided into two groups: 107 patients in the control group were treated with conventional massage combined with traction, and 104 patients in the observation group were treated with a combination of the control regimen and self-prescribed oral SPST. The patients were treated for 4 wk. Indices of traditional Chinese medicine (TCM) syndrome score and serum inflammatory factor levels were measured.
RESULTS: After therapy, the TCM syndrome score in the observation group was significantly lower than that in the control group (P < 0.05). The main symptoms, clinical signs, daily activities, and Japanese Orthopedic Association scores in the observation group were significantly higher than those in the control group after therapy (P < 0.05). The levels of tumor necrosis factor-α, interleukin-6, and C-reactive protein were lower in the observation group than in the control group (P < 0.05). In the observation group, superoxide dismutase levels were significantly higher, whereas malondialdehyde levels were significantly lower, compared with the control group (P < 0.05). The overall efficacy rate in the observation group was 96.15%, which was substantially higher than that in the control group (88.79%; P < 0.05).
CONCLUSIONS: Self-prescribed SPST can reduce the levels of inflammatory and pain-causing factors as well as lumbar pain in patients with LDH.
OBJECTIVE: To observe the clinical therapeutic effects on LDH treated with self-prescribed SPST.
METHODS: A total of 211 patients with LDH syndrome were divided into two groups: 107 patients in the control group were treated with conventional massage combined with traction, and 104 patients in the observation group were treated with a combination of the control regimen and self-prescribed oral SPST. The patients were treated for 4 wk. Indices of traditional Chinese medicine (TCM) syndrome score and serum inflammatory factor levels were measured.
RESULTS: After therapy, the TCM syndrome score in the observation group was significantly lower than that in the control group (P < 0.05). The main symptoms, clinical signs, daily activities, and Japanese Orthopedic Association scores in the observation group were significantly higher than those in the control group after therapy (P < 0.05). The levels of tumor necrosis factor-α, interleukin-6, and C-reactive protein were lower in the observation group than in the control group (P < 0.05). In the observation group, superoxide dismutase levels were significantly higher, whereas malondialdehyde levels were significantly lower, compared with the control group (P < 0.05). The overall efficacy rate in the observation group was 96.15%, which was substantially higher than that in the control group (88.79%; P < 0.05).
CONCLUSIONS: Self-prescribed SPST can reduce the levels of inflammatory and pain-causing factors as well as lumbar pain in patients with LDH.
摘要：
背景：腰椎间盘突出症（LDH）通常发生在脊柱手术期间；LDH在年轻患者中呈上升趋势，并被归类为“瘫痪”和“背痛”。“SanhanchushiTongbi（SPST）是一个定制的处方。它分散了寒冷，缓解疼痛,从经络和内脏中去除寒冷，治疗神经性疼痛。然而,很少有研究探讨其缓解疼痛的机制。
目的：观察自拟SPST治疗LDH的临床疗效。
方法：将211例LDH综合征患者分为两组，对照组107例采用常规推拿结合牵引治疗，观察组104例患者采用对照方案和自拟口服SPST联合治疗。患者治疗4周。测定中医证候积分指标及血清炎症因子水平。
结果：治疗后，观察组中医证候积分明显低于对照组(P<0.05)。主要症状,临床体征,日常活动,观察组治疗后日本骨科协会评分明显高于对照组(P<0.05)。肿瘤坏死因子-α的水平，观察组白细胞介素-6、C反应蛋白水平低于对照组(P<0.05)。在观察组中,超氧化物歧化酶水平明显更高，而丙二醛水平明显较低，与对照组比较(P<0.05)。观察组的总有效率为96.15%,显著高于对照组的88.79%(P<0.05)。
结论：自拟SPST可降低LDH患者的炎症和疼痛因子水平以及腰痛。
目的：观察自拟SPST治疗LDH的临床疗效。
方法：将211例LDH综合征患者分为两组，对照组107例采用常规推拿结合牵引治疗，观察组104例患者采用对照方案和自拟口服SPST联合治疗。患者治疗4周。测定中医证候积分指标及血清炎症因子水平。
结果：治疗后，观察组中医证候积分明显低于对照组(P<0.05)。主要症状,临床体征,日常活动,观察组治疗后日本骨科协会评分明显高于对照组(P<0.05)。肿瘤坏死因子-α的水平，观察组白细胞介素-6、C反应蛋白水平低于对照组(P<0.05)。在观察组中,超氧化物歧化酶水平明显更高，而丙二醛水平明显较低，与对照组比较(P<0.05)。观察组的总有效率为96.15%,显著高于对照组的88.79%(P<0.05)。
结论：自拟SPST可降低LDH患者的炎症和疼痛因子水平以及腰痛。
