Abstract：
Background: There is controversy on whether allergic contact dermatitis (ACD) is associated with atopy. Research on eczema and the risk of ACD is mixed, and there is sparse literature on other atopic conditions. Objective: Our study examined the prevalence of several atopic conditions, including allergic rhinitis, eczema, asthma, and food allergies in patients with ACD, and compared these to patients without ACD. Methods: We retrospectively reviewed adult patients ages ≥ 18 years with ACD (n = 162) with positive patch testing results and documented any history of atopy, including childhood eczema, asthma, allergic rhinitis, and immunoglobulin E-mediated food allergy. The prevalence of atopic conditions was compared between our ACD cohort and controls without ACD (n = 163) from our electronic medical records system (age and gender matched). Results: Among our patients with ACD, 53 (33%) had allergic rhinitis, 22 (14%) had childhood eczema, 32 (20%) had asthma, and 8 (5%) had food allergies. We observed that the odds of atopy overall (n = 76) in the ACD group compared with the control group were increased (odds ratio [OR] 1.88; p = 0.007). Allergic rhinitis was the highest risk factor (n = 53) with an OR of 12.64 (p < 0.001). Childhood eczema (n = 22) was also increased in the ACD group (OR 2.4; p = 0.026). The odds of asthma and food allergy in the ACD group were also increased; however, the difference was not statistically significant from the control group (OR 1.76 [p = 0.071] and OR 2.76 [p = 0.139], respectively). Conclusion: Patients with ACD had increased odds of eczema, allergic rhinitis, and atopic conditions overall. Asthma and food allergies were not found to have a statistically significant correlation. Larger studies that delve into atopic risk factors in ACD would be important to confirm these findings.
摘要：
背景：过敏性接触性皮炎（ACD）是否与特应性有关存在争议。湿疹与ACD风险的研究好坏参半,关于其他特应性疾病的文献很少。目的：我们的研究检查了几种特应性疾病的患病率，包括过敏性鼻炎,湿疹,哮喘,ACD患者的食物过敏，并将其与无ACD患者进行比较。方法：我们回顾性分析年龄≥18岁的ACD成年患者（n=162），斑贴检测结果为阳性，并记录任何特应性病史，包括儿童湿疹,哮喘,过敏性鼻炎,免疫球蛋白E介导的食物过敏。从我们的电子病历系统（年龄和性别匹配）中比较了我们的ACD队列和没有ACD的对照组（n=163）之间特应性疾病的患病率。结果：在我们的ACD患者中，53（33%）患有过敏性鼻炎，22人（14%）有儿童湿疹，32（20%）患有哮喘，和8（5％）有食物过敏。我们观察到，与对照组相比，ACD组的总体特应性（n=76）的几率增加（比值比[OR]1.88；p=0.007）。变应性鼻炎是最高的危险因素（n=53），OR为12.64（p<0.001）。ACD组儿童湿疹（n=22）也增加（OR2.4；p=0.026）。ACD组发生哮喘和食物过敏的几率也增加；然而，与对照组相比，差异无统计学意义（OR1.76[p=0.071]和OR2.76[p=0.139]，分别)。结论：ACD患者患湿疹的几率增加，过敏性鼻炎,和总体特应性条件。未发现哮喘和食物过敏具有统计学上的显着相关性。深入研究ACD中特应性危险因素的大型研究对于证实这些发现很重要。
