PDF(Pubmed)
Abstract：
Vascular tissue engineering is a promising approach for regenerating damaged blood vessels and developing new therapeutic approaches for heart disease treatment. To date, different sources of cells have been recognized that offer assistance within the recovery of heart supply routes and veins with distinctive capacities and are compelling for heart regeneration. However, some challenges still remain that need to be overcome to establish the full potential application of these cells. In this paper, we review the different cell sources used for vascular tissue engineering, focusing on extraembryonic tissue-derived cells (ESCs), and elucidate their roles in cardiovascular disease. In addition, we highlight the intricate interplay between mechanical and biochemical factors in regulating mesenchymal stem cell (MSC) differentiation, offering insights into optimizing their application in vascular tissues.
摘要：
血管组织工程是再生受损血管和开发新的心脏病治疗方法的一种有前途的方法。迄今为止,已经认识到不同的细胞来源，它们在心脏供应途径和静脉的恢复中提供帮助，具有独特的能力，并且对心脏再生具有吸引力。然而,一些挑战仍然存在，需要克服，以建立这些细胞的全部潜在应用。在本文中,我们回顾了用于血管组织工程的不同细胞来源，专注于胚胎外组织来源的细胞（ESC），并阐明它们在心血管疾病中的作用。此外,我们强调了调节间充质干细胞（MSC）分化的机械和生化因素之间的复杂相互作用，提供优化它们在血管组织中的应用的见解。
