PDF(Pubmed)
Abstract：
BACKGROUND: Exposure to poly- and perfluoroalkyl substances (PFAS) may affect infant and childhood health through immunosuppression. However, the findings of epidemiological literature examining relationships between prenatal/childhood PFAS exposure and vaccine response and infection in humans are still inconclusive. The aim of this review was to examine the effects of PFAS exposure on vaccine antibody response and infection in humans.
METHODS: The MEDLINE/Pubmed database was searched for publications until 1 February 2023 to identify human studies on PFAS exposure and human health. Eligible for inclusion studies had to have an epidemiological study design and must have performed logistic regression analyses of gestational or childhood exposure to PFAS against either antibody levels for pediatric vaccines or the occurrence of children\'s infectious diseases. Information on baseline exposure to PFAS (in ng/mL), the age of PFAS exposure (gestational or in years), and the outcome was measured, potentially leading to multiple exposure-outcome comparisons within each study was collected. Percentage change and standard errors of antibody titers and occurrence of infectious diseases per doubling of PFAS exposure were calculated, and a quality assessment of each study was performed.
RESULTS: Seventeen articles were identified matching the inclusion criteria and were included in the meta-analysis. In general, a small decrease in antibody response and some associations between PFAS exposure and childhood infections were observed.
CONCLUSIONS: This meta-analysis summarizes the findings of PFAS effects on infant and childhood immune health. The immunosuppression findings for infections yielded suggestive evidence related to PFAS exposure, particularly PFOS, PFOA, PFHxS, and PFNA but moderate to no evidence regarding antibody titer reduction.
BACKGROUND: The research protocol of this systematic review is registered and accessible at the Open Science Framework ( https://doi.org/10.17605/OSF.IO/5M2VU ).
METHODS: The MEDLINE/Pubmed database was searched for publications until 1 February 2023 to identify human studies on PFAS exposure and human health. Eligible for inclusion studies had to have an epidemiological study design and must have performed logistic regression analyses of gestational or childhood exposure to PFAS against either antibody levels for pediatric vaccines or the occurrence of children\'s infectious diseases. Information on baseline exposure to PFAS (in ng/mL), the age of PFAS exposure (gestational or in years), and the outcome was measured, potentially leading to multiple exposure-outcome comparisons within each study was collected. Percentage change and standard errors of antibody titers and occurrence of infectious diseases per doubling of PFAS exposure were calculated, and a quality assessment of each study was performed.
RESULTS: Seventeen articles were identified matching the inclusion criteria and were included in the meta-analysis. In general, a small decrease in antibody response and some associations between PFAS exposure and childhood infections were observed.
CONCLUSIONS: This meta-analysis summarizes the findings of PFAS effects on infant and childhood immune health. The immunosuppression findings for infections yielded suggestive evidence related to PFAS exposure, particularly PFOS, PFOA, PFHxS, and PFNA but moderate to no evidence regarding antibody titer reduction.
BACKGROUND: The research protocol of this systematic review is registered and accessible at the Open Science Framework ( https://doi.org/10.17605/OSF.IO/5M2VU ).
摘要：
背景：接触聚-和全氟烷基物质（PFAS）可能通过免疫抑制影响婴儿和儿童的健康。然而,流行病学文献研究了产前/儿童PFAS暴露与人类疫苗反应和感染之间的关系,结果仍然没有定论.这篇综述的目的是研究PFAS暴露对人类疫苗抗体反应和感染的影响。
方法：搜索MEDLINE/Pubmed数据库的出版物，直到2023年2月1日，以确定有关PFAS暴露和人类健康的人类研究。符合纳入研究条件的研究必须进行流行病学研究设计，并且必须针对儿童疫苗的抗体水平或儿童传染病的发生，对妊娠期或儿童期暴露于PFAS的logistic回归分析。关于PFAS基线暴露的信息（单位：ng/mL），PFAS暴露的年龄（妊娠或年），测量结果，我们收集了每项研究中可能导致多重暴露-结果比较的数据.计算了PFAS暴露每增加一倍的抗体滴度和传染病发生的百分比变化和标准误差，并对每项研究进行质量评估.
结果：确定了符合纳入标准的17篇文章，并纳入荟萃分析。总的来说,我们观察到抗体应答略有下降,并且PFAS暴露与儿童感染之间存在一些关联.
结论：本荟萃分析总结了PFAS对婴儿和儿童免疫健康的影响。感染的免疫抑制结果产生了与PFAS暴露有关的暗示性证据，特别是全氟辛烷磺酸，PFOA,PFHxS,和PFNA，但中度至没有关于抗体滴度降低的证据。
背景：本系统综述的研究协议已在开放科学框架（https://doi.org/10.17605/OSF）上注册并可访问。IO/5M2VU）。
方法：搜索MEDLINE/Pubmed数据库的出版物，直到2023年2月1日，以确定有关PFAS暴露和人类健康的人类研究。符合纳入研究条件的研究必须进行流行病学研究设计，并且必须针对儿童疫苗的抗体水平或儿童传染病的发生，对妊娠期或儿童期暴露于PFAS的logistic回归分析。关于PFAS基线暴露的信息（单位：ng/mL），PFAS暴露的年龄（妊娠或年），测量结果，我们收集了每项研究中可能导致多重暴露-结果比较的数据.计算了PFAS暴露每增加一倍的抗体滴度和传染病发生的百分比变化和标准误差，并对每项研究进行质量评估.
结果：确定了符合纳入标准的17篇文章，并纳入荟萃分析。总的来说,我们观察到抗体应答略有下降,并且PFAS暴露与儿童感染之间存在一些关联.
结论：本荟萃分析总结了PFAS对婴儿和儿童免疫健康的影响。感染的免疫抑制结果产生了与PFAS暴露有关的暗示性证据，特别是全氟辛烷磺酸，PFOA,PFHxS,和PFNA，但中度至没有关于抗体滴度降低的证据。
背景：本系统综述的研究协议已在开放科学框架（https://doi.org/10.17605/OSF）上注册并可访问。IO/5M2VU）。
