METHODS: Twenty-four patients with treatment-naïve renal tumours were imaged: seven renal oncocytomas (RO); one eosinophilic/oncocytic renal cell carcinoma; two chromophobe RCCs (chRCC); three papillary RCCs (pRCC); and twelve clear cell RCCs (ccRCC). Median, kurtosis, and skewness of T2 were quantified in tumours and in the normal-adjacent kidney cortex and were compared across renal tumour subtypes and between ccRCC grades.
RESULTS: High-resolution TEMPURA depicted the tumour structure at improved resolution compared to conventional T2-weighted imaging. The lowest median T2 values were present in pRCC (high-resolution, 51 ms; accelerated, 45 ms), which was significantly lower than RO (high-resolution; accelerated, p = 0.012) and ccRCC (high-resolution, p = 0.019; accelerated, p = 0.008). ROs showed the lowest kurtosis (high-resolution, 3.4; accelerated, 4.0), suggestive of low intratumoural heterogeneity. Lower T2 values were observed in higher compared to lower grade ccRCCs (grades 2, 3 and 4 on high-resolution, 209 ms, 151 ms, and 106 ms; on accelerated, 172 ms, 160 ms, and 102 ms, respectively), with accelerated TEMPURA showing statistical significance in comparison (p = 0.037).
CONCLUSIONS: Both high-resolution and accelerated TEMPURA showed marked potential to quantify differences across renal tumour subtypes and between ccRCC grades.
BACKGROUND: ClinicalTrials.gov, NCT03741426 . Registered on 13 November 2018.
CONCLUSIONS: The newly developed T2 mapping methods have improved resolution, shorter acquisition times, and promising quantifiable readouts to characterise incidental renal masses.
方法:对24例初治肾肿瘤患者进行成像:7例肾嗜酸细胞瘤(RO);1例嗜酸性/嗜酸性肾细胞癌;2例发色细胞RCC(chRCC);3例乳头状RCC(pRCC);12例透明细胞RCC(ccRCC)。median,峰度,在肿瘤和正常-邻近肾皮质中量化T2的偏度,并在肾脏肿瘤亚型和ccRCC等级之间进行比较。
结果:与常规T2加权成像相比,高分辨率TEMPURA以提高的分辨率描绘了肿瘤结构。pRCC中存在最低的T2中值(高分辨率,51ms;加速,45ms),显著低于RO(高分辨率;加速,p=0.012)和ccRCC(高分辨率,p=0.019;加速,p=0.008)。RO显示出最低的峰度(高分辨率,3.4;加速,4.0),提示肿瘤内异质性低。与较低等级的ccRCC相比,在较高的地方观察到较低的T2值(高分辨率的等级2、3和4,209毫秒,151ms,和106毫秒;在加速时,172ms,160ms,和102毫秒,分别),与加速TEMPURA相比显示统计学意义(p=0.037)。
结论:高分辨率TEMPURA和加速TEMPURA都显示出明显的潜力,可以量化肾脏肿瘤亚型之间和ccRCC等级之间的差异。
背景:ClinicalTrials.gov,NCT03741426。2018年11月13日注册。
结论:新开发的T2作图方法提高了分辨率,更短的采集时间,和有希望的可量化读数来表征偶然的肾脏肿块。